High Prevalence of Extensively Drug-resistant Acinetobacter baumannii at a Children Hospital in Bolivia

The Pediatric Infectious Disease Journal
Mónica CerezalesLucía Gallego

Abstract

Acinetobacter baumannii causes serious hospital-acquired infections and has been positioned as a priority organism by the World Health Organization. This study includes 36 A. baumannii isolates from a children hospital recovered between March 2014 and May 2015 in Cochabamba. The majority of the isolates were recovered from blood cultures (n = 10, 31.3%) and respiratory samples (n = 11, 34.4%); 53% of the patients were younger than 1 month old. Most of these isolates (n = 30, 80.6%) were extremely drug resistant and 8.3% were multidrug resistant. The circulation of 2 predominant clones including 25 isolates was determined by pulsed-field gel electrophoresis; 9 of the isolates were considered sporadic strains. The isolates grouped in the predominant clones and 5 of the unrelated sporadic strains were single-locus variant or double locus variant of clonal complex (CC110), belonging to international clone 7; the rest of the isolates were single-locus variant or double locus variant of another clonal complex. All the carbapenem-resistant isolates (88.9%) carried the blaOXA-23-like in a similar structure to Tn2008 located on the chromosome, and the aac(3)-IIa gene was present in all the aminoglycoside-resistant isolates (86.1%). Stro...Continue Reading

References

Jan 1, 1995·Antimicrobial Agents and Chemotherapy·C LévesqueP H Roy
Jul 25, 2003·Antimicrobial Agents and Chemotherapy·Marc GalimandThierry Lambert
Sep 8, 2005·Journal of Clinical Microbiology·Sergio G BartualFrancisco Rodríguez-Valera
Mar 28, 2006·International Journal of Antimicrobial Agents·Neil WoodfordDavid M Livermore
Apr 25, 2006·FEMS Microbiology Letters·Jane F TurtonTyrone L Pitt
Sep 7, 2006·Antimicrobial Agents and Chemotherapy·Chi Hye ParkDavid C Hooper
Dec 23, 2006·The Journal of Antimicrobial Chemotherapy·Matthew J EllingtonNeil Woodford
Jan 16, 2007·Antimicrobial Agents and Chemotherapy·Stéphane CorvecPatrice Nordmann
Jun 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yohei Doi, Yoshichika Arakawa
Jan 15, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B A EvansS G B Amyes
Jan 15, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J Rodríguez-BañoUNKNOWN Spanish Group for the Study of Nosocomial Infections (GEIH)
Dec 10, 2009·The Journal of Antimicrobial Chemotherapy·Paul G HigginsHarald Seifert
Dec 25, 2009·Emerging Infectious Diseases·Pauline D MugnierPatrice Nordmann
Jan 29, 2010·Journal of Clinical Microbiology·Kevin S AkersClinton K Murray
Feb 4, 2010·American Journal of Infection Control·Karina Eugênia Schimith BierLibera Maria Dalla Costa
Jul 29, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A-P MagiorakosD L Monnet
Jan 15, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·María Silvina StietzMariana Catalano
Apr 18, 2013·Journal of Infection in Developing Countries·Bruno Silvester LopesSebastian Giles Becket Amyes
Apr 4, 2014·Clinical Microbiology Reviews·Benjamin A Evans, Sebastian G B Amyes
Jan 13, 2016·The Journal of Antimicrobial Chemotherapy·Steven J Nigro, Ruth M Hall
Jul 21, 2016·Journal of Global Antimicrobial Resistance·Samanta SennatiLucia Pallecchi
Nov 26, 2016·Journal of Infection in Developing Countries·Elena SevillanoLucía Gallego
Dec 6, 2016·Expert Review of Anti-infective Therapy·Kevin Escandón-VargasMaría Virginia Villegas
Jun 27, 2017·The Pediatric Infectious Disease Journal·Charalampos Antachopoulos, Elias Iosifidis

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Citations

Sep 26, 2020·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·Julio Cesar Zuniga-MoyaLuis Enrique Romero
Nov 12, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Mariana Neri Lucas KuriharaSimone Simionatto

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