High prevalence of growth hormone deficiency in severe fibromyalgia syndromes

The Journal of Clinical Endocrinology and Metabolism
Guillem CuatrecasasM Puig-Domingo

Abstract

Fibromyalgia (FM) is characterized by widespread pain and fatigue and is considered a syndrome with different pathogenic mechanisms. Controversial data on GH axis disturbances have been published. Some preliminary trials have shown promising effects of GH therapy on tender points and quality of life in FM. The aim was to study the patterns of GH secretion/sensitivity in a cohort of severe FM patients. The study was conducted in five tertiary hospitals. A total of 493 FM women (1990 American College of Rheumatology criteria) recruited from five centers, having more than 16 tender points, Fibromyalgia Impact Questionnaire scores above 75, more than 1 yr of stable medication (serotonin reuptake inhibitors, amitriptyline, and opioids), and body mass index below 35 kg/m(2) underwent baseline IGF-I/GH determinations; an insulin tolerance test (ITT) and a modified IGF-I generation test were performed in those cases showing IGF-I of 150 microg/liter or less. A total of 169 of the 493 patients (34.2%) showed IGF-I of 150 microg/liter or less. Mean peak GH during ITT was 13.3 +/- 9.9 ng/ml in 127 patients in which the test was performed. In 22 of 127 (17.3%), ITT peak GH was 5 microg/ml or less, and in eight of them (6.3%), the peak GH w...Continue Reading

Citations

Jul 5, 2012·Der Schmerz·C SommerUNKNOWN Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften
May 1, 2013·Nature Reviews. Endocrinology·Fred Nyberg, Mathias Hallberg
Aug 29, 2012·QJM : Monthly Journal of the Association of Physicians·B Abbi, B H Natelson
Jan 18, 2012·Obesity Facts·Virginia A AparicioManuel Delgado-Fernández
Jan 18, 2014·Arthritis Research & Therapy·Winfried HäuserClaudia Sommer
Mar 29, 2014·Rheumatology International·Diogo HomannNeiva Leite
Feb 26, 2014·Brain Injury : [BI]·Dennis J ZgaljardicMelinda Sheffield-Moore
Oct 9, 2015·Clinical Reviews in Allergy & Immunology·Andrea T Borchers, M Eric Gershwin
Jun 15, 2016·Pain Management·Jacob N Ablin, Winfried Häuser
Jan 27, 2017·BMC Musculoskeletal Disorders·Kaisa MannerkorpiJan L Bjersing
Jan 8, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jijun XuJianguo Cheng
Mar 16, 2017·BMC Musculoskeletal Disorders·Jan L BjersingKaisa Mannerkorpi
Jul 27, 2017·International Journal of Endocrinology·Antonello E RigamontiAlessandro Sartorio
Oct 8, 2020·PM & R : the Journal of Injury, Function, and Rehabilitation·Liza Grosman-RimonDinesh Kumbhare
Aug 8, 2021·International Journal of Environmental Research and Public Health·Paulina GolanskaMonika Lukomska-Szymanska

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