PMID: 7538925Mar 1, 1995Paper

High prevalence of hepatitis C infection in Afro-Caribbean patients with type 2 diabetes and abnormal liver function tests

Diabetic Medicine : a Journal of the British Diabetic Association
H GrayS O'Rahilly

Abstract

Moderate elevations of serum transaminases are frequently found in patients with diabetes mellitus and are often attributed to fatty infiltration of the liver without further investigation. Recent studies of patients with end-stage liver disease have suggested a possible association between Hepatitis C virus (HCV) antibody positivity and the development of diabetes (mostly Type 2). As a first step in the examination of any potential association between HCV and Type 2 diabetes in subjects without overt liver disease, we examined 200 British patients with Type 2 diabetes (100 White Caucasians, 50 Asians, and 50 Afro-Caribbeans), recruited from the United Kingdom Prospective Study of Diabetes, half of whom had a significant elevation of alanine aminotransferase (ALT) on at least two occasions and half of whom had consistently normal ALT levels. In Afro-Caribbean Type 2 diabetic subjects 7/25 (28%) patients with abnormal ALT and 1/25 (4%) with normal ALT were HCV antibody positive. Among White Caucasian subjects 6/50 (12%) patients with abnormal LFTs and 0/50 with normal LFTs were HCV antibody positive and in Asians the prevalence was 2/25 (8%) and 0/25, respectively. This study suggests that persistent mild to moderate elevation o...Continue Reading

References

Mar 1, 1992·Clinical and Experimental Immunology·F Dammacco, D Sansonno
Jan 11, 1992·Lancet·S MaclennanM Contreras
Aug 15, 1991·The New England Journal of Medicine·B J PereiraA S Levey
Dec 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A M Di BisceglieH J Alter
Aug 1, 1990·The Journal of Infectious Diseases·M PascualJ A Schifferli
Oct 1, 1988·The Journal of Pathology·N Nagore, P J Scheuer
May 1, 1984·Diabetes Care·P I SalmelaO Mäentausta
Dec 1, 1993·Journal of the American Society of Nephrology : JASN·D M Burstein, R A Rodby
Jun 1, 1994·Journal of Hepatology·T G WreghittJ Wallwork
Feb 18, 1993·The New England Journal of Medicine·R J JohnsonC E Alpers
Jun 24, 1993·The New England Journal of Medicine·H TsukumaH Yamazaki

❮ Previous
Next ❯

Citations

Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L MasonR P Perrillo
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Hadziyannis, B Karamanos
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S CaroniaG J Alexander
Feb 16, 2008·Internal and Emergency Medicine·Amedeo LonardoNicola Carulli
May 11, 2004·Current Diabetes Reports·Gül BahtiyarSamy I McFarlane
Jan 15, 2004·Current Gastroenterology Reports·Vlad RatziuThierry Poynard
May 10, 2000·Diabetes Research and Clinical Practice·L SangiorgioM Lunetta
May 15, 1997·Transplantation·E A KendrickC L Davis
Sep 6, 2003·International Journal of Adolescent Medicine and Health·Mehmet Emre AtabekIbrahim Erkul
Jan 31, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L F GrecaJ L Gross
Apr 3, 2009·World Journal of Gastroenterology : WJG·Francesco Negro, Mahnaz Alaei
Jun 13, 2009·World Journal of Gastroenterology : WJG·Naoufel KaabiaAmel Letaief
Mar 4, 2014·World Journal of Gastroenterology : WJG·Nimzing G LadepMireille B Toledano
Mar 3, 2015·Indian Journal of Endocrinology and Metabolism·Demitrost LalooSalam Ranabir
May 13, 2006·Journal of the Chinese Medical Association : JCMA·Hua-Fen ChenHsin-Yu Lee
Oct 18, 2011·Journal of Infection and Public Health·Wassim ChehadehWidad Al-Nakib
Jul 6, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A LonardoP Loria
Apr 17, 2007·Journal of Hepatology·Terence T LaoKa-Yu Tse
Aug 12, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Aldo J Montano-LozaAndrew L Mason
Feb 23, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Fumio ImazekiHiromitsu Saisho
Mar 5, 2008·Journal of Thrombosis and Haemostasis : JTH·K KainE M Scott
Feb 16, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stephen A HarrisonJohn M Vierling
Jan 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Arun J Sanyal
Jul 18, 2008·Transplantation Reviews·Roy D Bloom, Michael F Crutchlow
Aug 12, 2006·Journal of Hepatology·Francesco Negro
Mar 1, 2006·Journal of Diabetes and Its Complications·Hiroshi Noto, Philip Raskin
Dec 3, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Patrice CacoubAnna Linda Zignego
Oct 11, 2012·Interdisciplinary Perspectives on Infectious Diseases·Solomon AliTamrat Abebe
May 20, 2008·American Journal of Obstetrics and Gynecology·Steven A PergamStephen E Hawes
Jul 29, 2016·BMC Health Services Research·Ebtesam M Ba-EssaNasser M Al-Daghri
Feb 20, 2003·The American Journal of Gastroenterology·Paul J Thuluvath, Preeti R John
Jul 29, 2008·Scandinavian Journal of Gastroenterology·Emmanuel A TsochatzisAthanasios J Archimandritis
Feb 4, 2014·Diabetes Research and Clinical Practice·Hala Ahmadieh, Sami T Azar
Dec 3, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Serhat AytugNajma Begum
Feb 20, 2003·The American Journal of Gastroenterology·Andrew Mason, Satheesh Nair
May 5, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·A SotiropoulosS I Pappas
Dec 29, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Paul J Thuluvath
Dec 22, 1998·The American Journal of Gastroenterology·N N Zein
Sep 17, 2008·European Journal of Gastroenterology & Hepatology·Jean-François CadranelDominique Capron

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Diabetic Medicine : a Journal of the British Diabetic Association
A SotiropoulosS I Pappas
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
A L MasonR P Perrillo
© 2021 Meta ULC. All rights reserved