Abstract
Neurofibromatosis type 1 (NF1) is one of the most common genetic diseases in humans and has widely variable expressivity. Oral manifestations are common, but there are no studies that investigated functional alterations in salivary glands in NF1. Our aim was to evaluate the salivary flow rate in NF1 individuals, comparing to a control group, and to investigate the possible causes and some consequences of salivary gland alteration. This is a case-control study that evaluated the salivary flow rate of NF1 individuals (n = 49) and compared to an age and sex-matched control group. We have also investigated the possible causes and consequences of hyposalivation in NF1 individuals through anamnesis, a specific questionnaire, physical examination, tongue coating evaluation and cytopathological exam to assess the prevalence of oral candidiasis. Hyposalivation at rest was present in 59% (29/49) of NF1 individuals in contrast to 22% (11/49) in the control group, being statistically significant (P <0.0001; Wilcoxon rank-sum test). The analysis of the adjusted residual showed that the prevalence of hyposalivation in NF1 individuals (46.9%) was 4-fold higher than in controls (10.2%). None of the possible causes of hyposalivation (medication...Continue Reading
References
Nov 1, 1987·Gut·P N FosterM Atkinson
Sep 1, 1988·Oral Surgery, Oral Medicine, and Oral Pathology·J A D'AmbrosioR S Young
Oct 1, 1984·Oral Surgery, Oral Medicine, and Oral Pathology·S D ShapiroV M Riccardi
May 1, 1995·Human Molecular Genetics·G DanglotA Bernheim
Nov 1, 2001·Journal of Clinical Periodontology·S Mantilla GómezG A van der Weijden
Mar 21, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Noriko KimuraItaru Kimura
Apr 24, 2004·British Dental Journal·K S G CunhaF M Oliveira
Sep 20, 2005·The Journal of Biological Chemistry·Tatsuya OzawaHideyuki Saya
Apr 28, 2006·Cell and Tissue Research·Virgínia O CremaMarinilce F Santos
May 24, 2007·Journal of Oral Rehabilitation·T ShimizuK Sakurai
Jul 1, 2008·Developmental Biology·Na XuMonn Monn Myat
Feb 2, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Kenichi OkazakiHitoshi Takahashi
Feb 19, 2010·Clinical Oral Investigations·Gert-Jan van der PuttenCees de Baat
Dec 24, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·B L S PiccianiM H Cantisano
Oct 14, 2011·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·C JosephM Muller-Bolla
Aug 9, 2012·BMC Oral Health·Christina Diogo LöfgrenCecilia Christersson
Oct 20, 2012·PloS One·Béatrice ValléeHélène Bénédetti
Apr 1, 2014·Critical Reviews in Oncology/hematology·Fawad JavedGeorgios E Romanos
Citations
Apr 28, 2018·Chinese Journal of Integrative Medicine·Su-Ryun Kim, Dong-Hyun Nam
Feb 20, 2018·Reports on Progress in Physics·Maurice Garcia-Sciveres, Norbert Wermes
Oct 12, 2017·Brazilian Oral Research·Cristhiane Olívia Ferreira do AmaralElizabeth Ferreira Martinez
Feb 20, 2021·Head & Face Medicine·Eloá Borges LunaKarin Soares Cunha
May 30, 2021·Clinical Oral Investigations·Larissa de Oliveira ReisAndréa de Castro Domingos