Abstract
The main objective of this study is to describe the presence of infections in patients with pulmonary haemorrhage and systemic lupus erythematosus. Patients with systemic lupus erythematosus and pulmonary haemorrhage were thoroughly evaluated in the first 48 hours with imaging plus bronchoscopy and bronchoalveolar fluid analysis. If needed, videoassisted thoracoscopy and lung biopsy were performed too. In all, search for bacterial, mycobacterial and fungal infections proceeded. Appropriate blood, bronchoalveolar fluid and tissue cultures were taken. Patients were treated with antibiotics and corticosteroids in case of infection. Otherwise, they received initial intravenous methylprednsiolone pulses for 3 days as standard therapy for pulmonary haemorrhage in systemic lupus erythematosus. Additional treatment with immunosuppressives was further decided by the treating physicians. Fourteen events in 13 patients were evaluated. In eight events (57%), an infection was demonstrated. Aetiological agents included Pseudomonas sp. and Aspergillus fumigatus. Four patients died, three of them because of the pulmonary infection and one because of cerebral haemorrhage secondary to severe systemic hypertension, 48 hours after methylprednisolo...Continue Reading
References
Jun 1, 1992·Arthritis and Rheumatism·C BombardierC H Chang
Apr 1, 1992·Seminars in Arthritis and Rheumatism·D Alarcón-SegoviaJ Cabiedes
Sep 1, 1987·Medicine·D B HellmannQ Whiting-O'Keefe
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Oct 1, 1994·Seminars in Arthritis and Rheumatism·R W EricksonW Emlen
Mar 1, 1996·Arthritis and Rheumatism·D GladmanA Zoma
Nov 1, 1996·Chest·R J GreenT A Raffin
May 1, 1997·Medicine·M R ZamoraM I Schwarz
Jan 1, 1997·Lupus·L A BarileJ M Miranda-Limón
Oct 27, 1997·Arthritis and Rheumatism·M C Hochberg
Jun 2, 1998·Rheumatic Diseases Clinics of North America·M Petri
Jun 30, 1998·Scandinavian Journal of Rheumatology·M FunauchiA Horiuchi
Sep 2, 1999·The Surgical Clinics of North America·M Rünzi, P Layer
Oct 18, 2000·Lupus·J Rojas-Serrano, M H Cardiel
Oct 18, 2000·Chest·A S Santos-OcampoB J Fessler
Mar 7, 2001·Arthritis and Rheumatism·J D Croft
Mar 22, 2001·Archives of Pathology & Laboratory Medicine·M D HughsonR McMurray
Nov 20, 2003·Seminars in Arthritis and Rheumatism·Chi Chiu MokWing Yin Lam
Dec 5, 2003·Lancet·Michail S Lionakis, Dimitrios P Kontoyiannis
Jun 11, 2004·Seminars in Arthritis and Rheumatism·Humeira BadshaHiok Hee Chng
Citations
Aug 20, 2010·Medical Mycology·Arunaloke ChakrabartiM R Shivaprakash
Apr 8, 2014·Reumatología clinica·Marco Ulises Martínez-Martínez, Carlos Abud-Mendoza
May 6, 2010·Chest·Abigail R Lara, Marvin I Schwarz
Aug 10, 2010·Clinics in Chest Medicine·Otylia Kowal-BieleckaElzbieta Chyczewska
Jul 29, 2011·Reumatología clinica·Mónica P SacnunBernardo A Pons-Estel
Jul 14, 2009·Best Practice & Research. Clinical Rheumatology·José María Pego-ReigosaDavid A Isenberg
Jun 2, 2009·Rheumatic Diseases Clinics of North America·Raquel Cuchacovich, Abraham Gedalia
Dec 3, 2014·Medicina clínica·Pablo Finucci CuriSergio Paira
Oct 18, 2016·Seminars in Arthritis and Rheumatism·Dam KimYoon-Kyoung Sung
Feb 18, 2014·Lupus·C Gonzalez-EchavarriG Ruiz-Irastorza
Aug 5, 2010·Lupus·G Vijatov-DjuricG Konstantinidis
May 12, 2011·Lupus·M U Martínez-Martínez, C Abud-Mendoza
Mar 31, 2012·Lupus·M U Martínez-Martínez, C Abud-Mendoza
Jun 20, 2018·Scandinavian Journal of Rheumatology·C-R WangH-W Tsai
Jul 6, 2014·The Journal of Rheumatology·Marco Ulises Martinez-MartinezCarlos Abud-Mendoza
Dec 7, 2018·The Journal of Rheumatology·Yi-Syuan SunChien-Chih Lai
Apr 12, 2017·Current Rheumatology Reports·Marco Ulises Martínez-MartínezCarlos Abud-Mendoza
Sep 10, 2019·International Journal of Rheumatic Diseases·Yeison Santamaria-AlzaClaudia Lucía Figueroa Pineda
Apr 20, 2017·Lupus·M J Haye SalinasUNKNOWN Grupo Latino Americano De Estudio del Lupus (GLADEL)
Aug 28, 2020·Current Rheumatology Reports·Estefania Calle-Botero, Andy Abril
Feb 11, 2020·Lupus·N K Al-Adhoubi, J Bystrom
Sep 16, 2020·Seminars in Arthritis and Rheumatism·Adam KilianAruni Jayatilleke
Apr 4, 2021·Pharmaceuticals·Salvatore Di BartolomeoFrancesco Carubbi
Nov 29, 2020·Reumatología clinica·Alejandro Antonio ReibaldiElena Fernández de Carrera