High prevalence of lactase non-persistence among indigenous nomadic Nenets, north-west Russia.

International Journal of Circumpolar Health
Yulia KhabarovaMauri Isokoski

Abstract

The frequency of adult-type hypolactasia (lactase non-persistence) varies widely among different ethnic groups. The cultural historical hypothesis assumes a link between the occurrence of hypolactasia and the distribution of dairy farming. The nomadic Nenets have been reindeer herders for generations and have therefore not consumed any dairy products. The hypotheses here was that the prevalence of lactase non-persistence (-13910 C/C genotype) among Nenets people having four Nenets grandparents is high, while the prevalence among Nenets originating from ethnically mixed families is lower. The material was collected in four typical Nenets settlements in the Nenets Autonomous Okrug in Russia. One-third of the adult Nenets population were invited to answer a questionnaire and to donate buccal samples for genotyping by a doctor from the team of medical professionals who make rounds in this area. The total number of available participants was 177. Genotyping was performed with the AbiPrism system. We used the method of concordance of grandparents' national origin to ascribe ethnicity. The prevalence of adult-type hypolactasia (-13910 C/C) among Nenets who had four Nenets grandparents was found to be 90%. The figures among others repo...Continue Reading

References

Jul 19, 1975·British Medical Journal·G C Cook, M T al-Torki
Jul 14, 1973·Lancet·G Flatz, H W Rotthauwe
Oct 13, 1973·Lancet·T SahiK Pyörälä
Nov 1, 1973·The American Journal of Clinical Nutrition·R R BellJ G Bergan
Jan 1, 1966·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·V N Arkhangelsky
Mar 1, 1995·Scandinavian Journal of Gastroenterology·M LemberM Isokoski
Jan 1, 1994·Scandinavian Journal of Gastroenterology. Supplement·T Sahi
Jul 30, 1994·BMJ : British Medical Journal·P A Senior, R Bhopal
Jan 15, 2002·Nature Genetics·Nabil Sabri EnattahIrma Järvelä
Nov 6, 2004·International Journal of Circumpolar Health·Andrew Kozlov
Nov 8, 2005·Scandinavian Journal of Clinical and Laboratory Investigation·I E Järvelä
Apr 17, 2009·World Journal of Gastroenterology : WJG·Yulia KhabarovaKari-Juhani Mattila Mattila
Dec 1, 2007·International Journal of Circumpolar Health·Andrew KozlovMaria Kozlova
Dec 1, 2007·International Journal of Circumpolar Health·Andrew KozlovMaria Kozlova

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
Assay

Software Mentioned

SPSS
Nenets

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.