High Prevalence of Leptotrichia amnionii , Atopobium vaginae , Sneathia sanguinegens , and Factor 1 Microbes and Association of Spontaneous Abortion among Korean Women

BioMed Research International
Sang Soo SeoJae Kwan Lee

Abstract

Objective. The purpose of this study was to (i) determine the cervical microbial composition in different abortion samples and to (ii) investigate the correlation between spontaneous abortion and cervical microbes in Korean women. Methods. We collected cervical swabs from women who had never undergone abortion (N = 36), had spontaneous abortion (N = 23), and had undergone induced abortion (N = 88) and subjected those samples to 16S rRNA pyrosequencing. Further, factor analysis and correlation between cervical microbiota and spontaneous abortion were evaluated by logistic regression analysis. Results. In spontaneous abortion women, 16 S rRNA gene sequences showed significant increases in Atopobium vaginae, Megasphaera spp., Gardnerella vaginalis, Leptotrichia amnionii, and Sneathia sanguinegens compared to women in nonabortion group. In multivariate logistic regression analysis, A. vaginae (OD = 11.27; 95% = 1.57-81), L. amnionii (OD = 11.47; 95% = 1.22-107.94), S. sanguinegens (OD = 6.89; 95% = 1.07-44.33), and factor 1 microbes (OD = 16.4; 95% = 1.88-42.5) were strongly associated with spontaneous abortion. Conclusions. This study showed a high prevalence of L. amnionii, A. vaginae, S. sanguinegens, and factor 1 microbes in sp...Continue Reading

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Citations

Apr 16, 2020·Journal of Bacteriology·Gabriella L GentileKimberly K Jefferson
Dec 29, 2020·Frontiers in Cellular and Infection Microbiology·Yupei XieTingtao Chen
Jun 8, 2021·Frontiers in Cellular and Infection Microbiology·Shakti KumarUNKNOWN GARBH-Ini Study Group
Sep 8, 2021·Frontiers in Cellular and Infection Microbiology·Fuju ZhaoChunmei Ying

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Methods Mentioned

BETA
PCR
electrophoresis
Assay
hormone replacement therapy

Software Mentioned

SAS
house Perl scripts

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