High prevalence of morphological subtype FAB M1 in adults with de novo acute myeloid leukemia in São José dos Campos, São Paulo

São Paulo Medical Journal = Revista Paulista De Medicina
Fernando CalleraCláudio Marcelo Tavares Pessoa de Melo

Abstract

Geographical variations have been described in acute myelogenous leukemia (AML). In Brazil, few studies have been published on this. The aim of this study was to demonstrate the high prevalence of French-American-British (FAB) M1 subtype in adults with de novo AML in São José dos Campos, State of São Paulo, Brazil. Retrospective analysis, at Hospital Pio XII in São José dos Campos, a public non-teaching institution. Records from 39 consecutive adult patients with de novo AML referred to Hospital Pio XII between January 2002 and September 2004 were reviewed. Peripheral blood and blood marrow smears were reviewed blindly by five hematologists and classified according to FAB criteria. The rates of remission, relapse, mortality according treatment phase, survival and leukemia-free survival were calculated. The prevalence of each category as determined via a consensus among five observers was M0: 0%; M1: 43.6%; M2: 30.7%; M3: 12.8%; M4: 5.1%; M5: 2.6%: M6: 2.6%; and M7: 2.6%. The remission and the relapse rates were 82% and 41% respectively. The mortality rate was 69% (induction of remission: 7/39, 17.9%; post induction: 10/32, 31.2%; and relapse: 10/16, 62.5%). The survival rate was 30% and leukemia-free survival was 33%. The study...Continue Reading

References

Mar 18, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M F N RegoI Lorand-Metze

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Citations

Jun 5, 2013·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Dalia A Salem, Sherin M Abd El-Aziz
Jan 1, 2011·Revista brasileira de hematologia e hemoterapia·Fernando CalleraThais Domitila Freire Vieira
Jan 10, 2016·Acta Tropica·José BermudezSantiago Palma
Dec 13, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Mohammad MoslehRoohollah Gholampour
Jan 18, 2012·São Paulo Medical Journal = Revista Paulista De Medicina·Elda Pereira NoronhaRaimundo Antônio Gomes Oliveira

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