Abstract
One-third of 57 strains of pneumococci isolated from patients with severe pneumococcal infections in Port Moresby, Papua New Guinea, in 1978 were penicillin-insensitive (PR). The infections were community-acquired and comprised cases of bacteraemia, bacteraemic pneumonia, and meningitis. The prevalence of invasive PR strains in children was significantly greater than in adults. Twenty-one serotypes were identified, of which ten types (6, 9, 10, 12-14, 18, 19, 23, 24) showed diminished sensitivity to penicillin; with types 12 and 18 penicillin-insensitivity has not been met with previously in Papua New Guinea and only rarely elsewhere; seven of the 19 PR strains belonged to type 6. Amongst insensitive strains, minimum inhibitory concentrations of penicillin G ranged from 0.1 to 1.0 microgram/ml (resistance ratios 5 to 50). Resistance to chloramphenicol and other antimicrobial drugs was not encountered.
References
Apr 24, 1976·British Medical Journal·V J Howes, R G Mitchell
Oct 5, 1978·The New England Journal of Medicine·M R JacobsR Austrian
Feb 1, 1979·American Journal of Diseases of Children·G A AhronheimM I Marks
Nov 12, 1977·Lancet·P C AppelbaumR C Cooper
Aug 25, 1977·The New England Journal of Medicine·J P Hieber, J D Nelson
Nov 1, 1974·The Journal of Pediatrics·S NaraqiS Kabins
Jan 28, 1971·The New England Journal of Medicine·D HansmanR Douglas
May 1, 1994·Indian Journal of Pediatrics·M Hiranandani, I Kaur
Dec 21, 1963·Lancet·G C TURNER
Citations
Aug 1, 1987·European Journal of Clinical Microbiology·P C Appelbaum
Nov 1, 1993·Journal of General Internal Medicine·G M CaputoM R Weitekamp
Jul 9, 2013·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Anne E MillerJoseph Vyankandondera
Feb 21, 2002·Lancet·Trevor DukeTilda Wal
Sep 8, 1984·Lancet·F ShannR Payne
Sep 28, 1985·Lancet·F ShannP Poore
Dec 1, 1985·The Journal of Hygiene·D HansmanB McDonald
Aug 12, 1999·Tropical Medicine & International Health : TM & IH·L Muhe, K P Klugman
Aug 1, 1985·Antimicrobial Agents and Chemotherapy·C LatorreI Sanfeliu
May 27, 2003·Archives of Disease in Childhood·T DukeJ Reeder
Jan 10, 2008·BMJ : British Medical Journal·Rai AsgharUNKNOWN Severe Pneumonia Evaluation Antimicrobial Research Study Group
Jan 24, 2004·Annals of Tropical Paediatrics·David G FullerNigel Curtis
Apr 1, 1995·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·E Bouza, P Muñoz
Feb 1, 1982·Australian and New Zealand Journal of Medicine·C W Clarke, G E Marlin
Nov 11, 1998·Tropical Medicine & International Health : TM & IH·P SapakM Waranduo
Feb 21, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Malihe TalebiMohammad Reza Pourshafie
Jul 2, 1987·The New England Journal of Medicine·R PallaresP F Viladrich
Mar 22, 2019·Antibiotics·Nicola D FoxleeColleen L Lau
Jan 1, 1984·Scandinavian Journal of Infectious Diseases·M KalinI Karlsson
Sep 1, 1997·Microbial Pathogenesis·H Y WuD E Briles