High prevalence of primary biliary cirrhosis and disease-associated autoantibodies in Japanese patients with systemic sclerosis

Modern Rheumatology
Sayako Imura-KumadaManabu Fujimoto

Abstract

To investigate the prevalence of primary biliary cirrhosis (PBC) and PBC-associated autoantibodies in Japanese systemic sclerosis (SSc) patients. Clinical data from 225 Japanese SSc patients were retrospectively obtained. Serum samples from these patients were examined for PBC-associated autoantibodies, anti-mitochondrial M2 antibodies (AMA), anti-sp100 antibodies (anti-sp100), and anti-gp210 antibodies (anti-gp210) by enzyme-linked immunosorbent assay. Of 225 patients, 37 (16.4%) had AMA, 13 (5.8%) had anti-sp100, and 3 (1.3%) had anti-gp210. Three patients were positive for both AMA and anti-sp100, and 2 were positive for both AMA and anti-gp210. PBC was found in 22 (9.8%) patients positive for AMA with or without anti-sp100 or anti-gp210, but not in those with anti-sp100 or anti-gp210 without AMA. Furthermore, 13 patients lacking these three antibodies were diagnosed with or suspected of PBC by liver biopsy and/or their clinical manifestation. Multivariable analysis revealed that AMA and anti-centromere antibodies were independently associated with PBC in SSc patients, while anti-sp100 and anti-gp210 were not. This study has demonstrated even higher prevalence of both PBC-associated autoantibodies and PBC in the Japanese SSc...Continue Reading

References

Jun 1, 1991·Arthritis and Rheumatism·J EvansJ Craft
Aug 1, 1970·British Medical Journal·I M Murray-LyonR Williams
Mar 1, 1971·The American Journal of Medicine·T B ReynoldsR L Peters
Apr 1, 1995·Immunological Reviews·R L Coppel, M E Gershwin
May 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O BandinC Johanet
Nov 15, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D ZüchnerH Will
Mar 6, 1998·British Journal of Rheumatology·S JacobsenJ Petersen
Jun 14, 2000·Internal Medicine·Y AkiyamaT Suzuki
Apr 23, 2002·Journal of Gastroenterology and Hepatology·Manuela NeumanKeith Lindor
Jul 10, 2003·Autoimmunity Reviews·Howard J Worman, Jean Claude Courvalin
Jun 23, 2004·QJM : Monthly Journal of the Association of Physicians·F E WattD E J Jones
Sep 24, 2005·The New England Journal of Medicine·Marshall M Kaplan, M Eric Gershwin
Aug 22, 2006·Autoimmunity Reviews·Yuki MoritokiM Eric Gershwin
Dec 26, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Minoru NakamuraHiromi Ishibashi
Mar 3, 2007·The Journal of Clinical Investigation·John Varga, David Abraham
Jul 14, 2007·Journal of Dermatological Science·Hironobu Ihn
Apr 2, 2009·Nature Reviews. Rheumatology·John Varga, Boris Pasche
Apr 10, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G L NormanP Milkiewicz
Jul 17, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M G Mytilinaiou, D P Bogdanos
Jun 5, 2010·Journal of Medical Genetics·Caroline Gaudy-MarquesteAnnachiara De Sandre-Giovannoli
Nov 26, 2010·Annual Review of Pathology·Tamiko R KatsumotoM Kari Connolly

❮ Previous
Next ❯

Citations

Feb 7, 2013·International Archives of Medicine·Sonia HammamiHamouda Saffar
Nov 14, 2013·World Journal of Gastroenterology : WJG·Xin-Ping Tian, Xuan Zhang
Jul 6, 2014·PloS One·Kenneth Andrew Ross
Jun 25, 2013·Autoimmunity Reviews·Muriel ElhaiYannick Allanore
Dec 7, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiromasa Ohira, Hiroshi Watanabe
Oct 5, 2013·Best Practice & Research. Clinical Gastroenterology·Maria De SantisCarlo Selmi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.