High prevalence of primary Enfuvirtide (ENF) resistance-associated mutations in HIV-1-infected patients in Hong Kong

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
P H M LeungW C Yam

Abstract

Enfuvirtide (ENF) is a viral fusion inhibitor used in patients failing highly active antiretroviral therapy (HAART). Mutations associated with ENF resistance have been identified within amino acid positions 36-45 of gp41. As ENF will be introduced to Hong Kong, an understanding of the prevalence of naturally occurred ENF resistance mutations is important before implementation of ENF treatment. To investigate the prevalence of ENF resistance-associated mutations in the HR1 and HR2 of HIV-1 strains obtained from ENF-naïve patients. HIV-1 strains isolated from 185 patients (156 antiretroviral treatment [ART]-naïve and 29 HAART-experienced) were screened for ENF resistance-associated mutations using RT-PCR and DNA sequencing. Primary mutations were detected in 19.4% of HARRT-experienced patients and 20.5% of ART-naïve patients. G36D was encountered most frequently and more prevalent in non-B subtypes. N42S, L54M and V69I were the major polymorphisms detected. N42S and L54M were predominant in CRF01_AE and subtype B, respectively. V69I was found in all samples harboring G36D. In three longitudinal samples from an ENF-treated patient, G36D was detected after ENF treatment for 6 months and the mutation persisted after termination of E...Continue Reading

References

Jun 10, 2004·AIDS Research and Human Retroviruses·Tonie CilliersLynn Morris
Jul 3, 2004·The Journal of Antimicrobial Chemotherapy·Michael L Greenberg, Nick Cammack
Feb 22, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·R CarmonaR Nájera
Jan 3, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·W C YamK Y Yuen
Apr 24, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·J H K ChenW C Yam
Aug 1, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Matthew KayeChris Birch

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