PMID: 9422332Jan 9, 1998Paper

High prevalence of thyroid autoantibodies at diagnosis of insulin-dependent diabetes mellitus in Swedish children

The Journal of Laboratory and Clinical Medicine
B LindbergS A Ivarsson

Abstract

The prevalence of thyroglobulin autoantibodies and that of thyroid peroxidase autoantibodies were studied in serum samples from 52 children with insulin-dependent diabetes mellitus, sampled at diagnosis and before the start of insulin treatment, with 386 non-diabetic schoolchildren (11 to 13 years of age) serving as control subjects. Using exactly the same sensitive solid-phase immunosorbent radioassay for both thyroid autoantibodies, with comparable sensitivity, we found the prevalences of both autoantibodies to be higher in the insulin-dependent diabetes mellitus group than in the control group, the difference being most pronounced for thyroid peroxidase autoantibodies. Thyroglobulin autoantibodies were positive in 33% of the diabetics versus 14% in the control group (p = 0.002), and thyroid peroxidase autoantibodies were positive in 38% versus 6% (p = 0.0001). The high prevalence of thyroid autoantibodies already at diagnosis stresses the importance of early screening for thyroid disease in patients with insulin-dependent diabetes mellitus.

References

Jan 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·M A AbdullahA Abanamy
Jan 1, 1989·Genetic Epidemiology·H PayamiG Thomson
Dec 1, 1986·American Journal of Diseases of Children·S D FrasierD Graves
Feb 1, 1973·Acta Endocrinologica·J Nerup, C Binder
Aug 1, 1984·The Journal of Pediatrics·B B GilaniN K MacLaren
Oct 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·U B EricssonJ I Thorell
Dec 1, 1983·The Tohoku Journal of Experimental Medicine·M NakazonoK Takebe
Jan 1, 1982·The Journal of Pediatrics·G M BrightW L Clarke
Sep 1, 1981·The Journal of Pediatrics·W J RileyA L Rosenbloom
Mar 1, 1996·Journal of Pediatric Endocrinology & Metabolism : JPEM·R LoriniA Scaramuzza
Jan 1, 1963·The Journal of Clinical Endocrinology and Metabolism·B H LANDINGG M GUEST

❮ Previous
Next ❯

Citations

May 1, 2001·Thyroid : Official Journal of the American Thyroid Association·B LindbergS A Ivarsson
Jun 10, 2004·Thyroid : Official Journal of the American Thyroid Association·Johan SvenssonSten-A Ivarsson
Apr 29, 1999·Current Opinion in Obstetrics & Gynecology·J H Mestman
Feb 21, 2013·Case Reports in Endocrinology·Yin H OoChristine A Resta
Jun 21, 2007·Upsala Journal of Medical Sciences·G ErtenM T Yilmaz
Jul 26, 2011·Journal of Thyroid Research·Mirella HageSami T Azar
Dec 14, 2011·Endocrine Research·Wahiba SaklyIbtissem Ghedira
Aug 1, 2014·Annals of Pediatric Endocrinology & Metabolism·Eui Seok JungChan Jong Kim
Jan 5, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L CairnsR Hajjeh
Nov 8, 2002·Mycoses·H SridharB R VijayKumar
Apr 20, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·P S MenonM Kaur
Sep 27, 2005·Arquivos brasileiros de endocrinologia e metabologia·Otton Luis Raffo SouzaHenriqueta G G de Almeida

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.