High prevalence of undiagnosed diabetes mellitus in Southern Germany: target populations for efficient screening. The KORA survey 2000

Diabetologia
W RathmannG Giani

Abstract

To estimate the prevalence of undiagnosed diabetes mellitus, impaired glucose tolerance (IGT) and impaired fasting glucose (IFG), and their relations with cardiovascular risk factors in the general population aged 55 to 74 years in Southern Germany. Oral glucose tolerance tests were carried out in a random sample of 1353 subjects aged 55 to 74 years participating in the KORA (Cooperative Health Research in the Region of Augsburg) Survey 2000. Prevalences of glucose tolerance categories (1999 WHO criteria) were adjusted for sample probabilities. The numbers needed to screen (NNTS) to identify one person with undiagnosed diabetes were estimated from age-adjusted logistic regression models. Sample design-based prevalences of known and unknown diabetes, IGT, and IFG were 9.0%, 9.7%, 16.8%, 9.8% in men, and 7.9%, 6.9%, 16.0%, 4.5% in women, respectively. In both sexes, participants with undiagnosed diabetes had higher BMI, waist circumference, systolic blood pressure, triglycerides, uric acid, and lower HDL-cholesterol than normoglycaemic subjects. A combination of abdominal adiposity, hypertension, and parental diabetes in men resulted in a NNTS of 2.9 (95%CI: 2.0-4.6). In women, the combination of increased triglycerides, hyperten...Continue Reading

References

Jan 1, 1989·International Journal of Epidemiology·U Keil, K Kuulasmaa
Sep 1, 1995·Obesity Research·J C Seidell
Aug 5, 1999·American Journal of Public Health·R C KlesgesC K Haddock
Feb 23, 2000·Journal of Cataract and Refractive Surgery·A FrohnH J Thiel
Aug 10, 2000·Diabetes/metabolism Research and Reviews·M I Harris, R C Eastman
Apr 6, 2001·Diabetes Care·K A McAuleyA W Duncan
Apr 20, 2001·BMJ : British Medical Journal·N J Wareham, S J Griffin
Sep 8, 2001·BMJ : British Medical Journal·J M LawrenceA M Robinson
Sep 26, 2001·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·H HaunerK H Feldhoff
Nov 28, 2001·Diabetes Care·L V FranseUNKNOWN Health, Aging, and Body Composition Study Group
Feb 5, 2002·Archives of Internal Medicine·Christa MeisingerHannelore Löwel
Jul 24, 2002·Diabetologia·B Jönsson, UNKNOWN CODE-2 Advisory Board
Jul 1, 2002·Diabetologia·B Jönsson

❮ Previous
Next ❯

Citations

Sep 4, 2013·International Journal of Public Health·Michael LaxyMatthias Hunger
Apr 15, 2014·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Matthias HungerMichaela Schunk
Jun 12, 2012·European Journal of Nutrition·Heiner BoeingBernhard Watzl
Sep 2, 2014·Metabolomics : Official Journal of the Metabolomic Society·Noha A YousriKarsten Suhre
Feb 12, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Dan ZieglerUNKNOWN KORA Study Group
Sep 29, 2004·Diabetes Care·Wolfgang Rathmann, Guido Giani
Jun 29, 2005·Diabetes Care·Wolfgang RathmannHannelore Löwel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.