High prevalence of VKORC1*3 (G9041A) genetic polymorphism in north Indians: A study on patients with cardiac disorders on acenocoumarol

Drug Discoveries & Therapeutics
Tushar SehgalNeelam Varma

Abstract

Coumarin derivatives such as warfarin and acenocoumarol are used in various disorders such as deep venous thrombosis, pulmonary embolism, atrial fibrillation and artificial heart valves. They have improved prognosis of patients with thromboembolic disease. An individual's response to coumarins depends on several factors. The non-genetic factors include age, gender, body mass index, diet and interacting drugs. Among the genetic factors, the cytochrome P450 system and vitamin K epoxide reductase complex subunit 1 play a key role in drug metabolism. This was a prospective hospital based study in which allele and genotypic frequencies of CYP2C9 gene polymorphisms; 430C>T and 1075A>C and VKORC1 gene polymorphisms; 1639G>A, 9041G>A and 6009C>T in 106 alleles of north Indian patients with valve replacement on acenocoumarol were determined and their effect on acenocoumarol dosing was studied. To the best of our knowledge, this is first report of VKORC1 9041G>A and 6009C>T gene polymorphisms and their effect on acenocoumarol dosing from north India. In 53 patients with valve replacement on acenocoumarol with stable INR, the allele frequency of CYP2C9*2 and CYP2C9*3 gene polymorphisms was 0.05 and 0.17 respectively and that of VKORC1 *2,...Continue Reading

References

Aug 1, 1992·Journal of Clinical Pathology·A H JamesS G Thompson
Oct 1, 1984·British Journal of Clinical Pharmacology·M ArboixM Rutllan
Aug 1, 1996·Pharmacogenetics·T H Sullivan-KloseJ A Goldstein
Mar 21, 2000·British Medical Bulletin·C R Wolf, G Smith
Jun 3, 2005·The New England Journal of Medicine·Mark J RiederAllan E Rettie
Mar 4, 2006·Clinical Pharmacology and Therapeutics·Soo-Chin LeeBoon-Cher Goh
May 28, 2010·Pharmacogenomics·Stuart A ScottRobert J Desnick
Mar 12, 2013·Thrombosis Research·Dhakchinamoorthi Krishna KumarChandrasekaran Adithan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.