High prevelance of chronic magnesium deficiency in T cell lymphoblastic leukemia and chronic zinc deficiency in children with acute lymphoblastic leukemia and malignant lymphoma

Leukemia & Lymphoma
G SahinN Yüksek

Abstract

Magnesium and zinc are the elements having essential roles in regulation of cell growth, division and differentiation. There have been some studies in the literature suggesting an association between the deficiency of these elements and the development of malignant disorders. In this study hair and serum zinc and magnesium levels were investigated in children with acute lymphoblastic leukemia (ALL) and malignant lymphoma (ML) at the time of initial diagnosis. Ten children with T-cell ALL, 10 children with B-precursor ALL, 5 children with Burkitt's Lymphoma (BL), 11 children with Hodgkin's lymphoma (HL), 10 children with non-Burkitt non-Hodgkin's lymphoma (NBNHL) and 12 age and sex matched healthy children as a control group were included in the study. Mean hair magnesium levels in all of the groups of the patients were lower than the levels in the control group but the difference was statistically significant only in the children with T cell ALL comparable to the controls (28.9+/-3.9 microg/g and 87.6+/-18.5 microg/g respectiveley, p<0,05). Mean serum magnesium levels in all the cohorts were not significantly different than those in controls (p>0.05 in each comparison). Mean hair zinc levels in the patients with T-cell, B-precu...Continue Reading

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Citations

Mar 14, 2007·Journal of the American College of Nutrition·Chanda D GokhaleSuresh H Advani
Aug 21, 2013·BioMed Research International·Emine Guven MaiorovAttila Gursoy
Sep 4, 2015·Biological Trace Element Research·Zahra KhoshdelMahyar Malekzadeh
Dec 25, 2008·Toxicology and Industrial Health·Y YangX M Shen
Dec 25, 2010·Journal of Biochemical and Molecular Toxicology·Maged BarakatJackleen Raafat
Dec 30, 2014·Physiological Reviews·Jeroen H F de BaaijRené J M Bindels
Aug 11, 2019·Biological Trace Element Research·Tolga AtakulCigdem Yenisey
Apr 24, 2018·Biological Trace Element Research·Hasan Imran AfridiFarah Naz Talpur
Oct 1, 2020·International Journal of Molecular Sciences·Fabiana da Silva Lima, Ricardo Ambrósio Fock
Jun 2, 2021·Pediatric Blood & Cancer·Jong H ChungEllen B Fung

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