PMID: 9537473Apr 16, 1998Paper

High proportion of granzyme B-positive (activated) intraepithelial and lamina propria lymphocytes in lymphocytic gastritis

The American Journal of Surgical Pathology
G OberhuberH Vogelsang

Abstract

Intraepithelial lymphocytes (IELs) and lamina propria lymphocytes (LpLs) have not been well studied in gastric mucosa, particularly in lymphocytic gastritis. Therefore, they were immunohistologically characterized with antibodies recognizing CD3, CD8, CD57, T cell-restricted intracellular antigen (TIA-1), and granzyme B (GrB). The TIA-1 labels cytotoxic granules of resting and activated T-cells, whereas GrB decorates activated cytotoxic T cells. Thirty patients with celiac disease, including 20 taking gluten and 10 on a gluten-free diet, 15 patients with nonceliac disease-associated lymphocytic gastritis, and 20 controls were studied. Stained cells were counted and results were given as IELs/100 epithelial cells or percentage of lamina propria cells. Sixty percent to 90% of CD3+ IELs and up to 12% of lamina propria cells contained TIA-1-positive cytotoxic granules. The number of GrB+ IELs and LpLs was increased in Helicobacter pylori-positive controls (p < 0.03 vs. H pylori-negative controls) and celiac disease patients taking gluten (p < 0.05 vs. controls). The highest number of GrB+ IELs and LpLs was found in nonceliac disease-associated lymphocytic gastritis (p < 0.009 vs. controls, p < 0.05 vs. celiac disease). This study s...Continue Reading

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Citations

Sep 16, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G Oberhuber
Apr 2, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lorenzo MemeoGovind Bhagat
Sep 13, 2001·Alimentary Pharmacology & Therapeutics·H VogelsangG Oberhuber
Apr 29, 1998·Journal of Women's Health
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Aug 6, 1999·The American Journal of Surgical Pathology·G OberhuberM Stolte
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Sep 16, 2000·Acta medica Austriaca·G Oberhuber, A Haidenthaler

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