High Proportion of Indeterminate QuantiFERON-TB Gold In-Tube Results in an Inpatient Population Is Related to Host Factors and Preanalytical Steps

Open Forum Infectious Diseases
Valeria FabreMaunank Shah

Abstract

QuantiFERON-TB Gold In-Tube test (QFT-GIT) can be used as an alternative to tuberculin skin testing (TST) for the targeted testing of latent tuberculosis. Due to many shortcomings with TST, QFT-GIT usage is increasing. QFT-GIT implementation in the inpatient setting remains unclear. We retrospectively identified patients admitted to a tertiary care academic center who received either a TST or a QFT-GIT in the 18 months prior to and after QFT-GIT implementation in March 2012. Risk factors associated with indeterminate results were evaluated. The proportion of inpatients receiving a test for tuberculosis infection doubled following QFT-GIT implementation (1.4% vs 2.9%). After QFT-GIT became available, 75% of tested people received a QFT-GIT and 25% received a TST. We found indeterminate test results in 19.8%. Independent predictors of indeterminate results were female sex (adjusted odds ratio [AOR], 1.64), lymphopenia (AOR, 2.21), hypoalbuminemia (AOR, 6.81) and sample collection by nonphlebotomists (AOR, 3.0, vs phlebotomists). Of patients who had indeterminate results, 42% had a subsequent indeterminate result on repeat testing. All indeterminate results were due to a low mitogen response. QFT-GIT testing in the inpatient setti...Continue Reading

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Citations

Jan 26, 2016·Scientific Reports·Chun-Ta HuangChong-Jen Yu
Oct 24, 2018·Human Vaccines & Immunotherapeutics·John M McLaughlinLuis Jodar
Jan 14, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joung Ha ParkSung-Han Kim
May 8, 2018·Pediatrics·Alexander W KayPennan M Barry

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

QFT
Stata
GIT

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