High-protein diet associated with resistance training reduces cardiac TNF-α levels and up-regulates MMP-2 activity in rats.

Archives of Physiology and Biochemistry
Murilo Esteves NogueiraJeeser Alves Almeida

Abstract

The consumption of high-protein diets (HPD) is associated with resistance training (RT) due to effects on metabolism. However, little is known about these effects on cardiac tissue. This study aimed to investigate effects of HPD and RT on cardiac biomarkers. 18 rats were divided into normo-protein (NPD), and HPD groups: NPD-Control, NPD-RT, HPD-Control, and HPD-RT. Interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-a), nitric oxide (NO), activity of metalloproteinase-2 (MMP-2), and vascular factor (VEGF) were analysed. RT was effective in regulating body weight, increasing strength, and reducing food consumption (p < .05). HPD induces higher levels of interleukin 6 (p = .0169), and lowers NO (p < .0001). When associated with RT, the HPD decreases levels of tumour necrosis factor alpha, while enhances NO, and MMP activity (p < .05). The association of RT with HDP decreases inflammatory parameters and indicates an enhancement in the molecular parameters of cardiac tissue.

References

Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Dec 25, 2002·The American Journal of Clinical Nutrition·William M RandVernon R Young
Feb 13, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Andrzej M JanczewskiArthur M Feldman
May 23, 2003·The New England Journal of Medicine·Gary D FosterSamuel Klein
Jan 27, 2005·The American Journal of Emergency Medicine·William G FernandezWilliam K Chiang
Mar 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Malgorzata MilkiewiczHaley Silgram
Jul 19, 2008·The New England Journal of Medicine·Iris ShaiUNKNOWN Dietary Intervention Randomized Controlled Trial (DIRECT) Group
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Shi Yin FooAnthony Rosenzweig
Aug 18, 2010·Circulation·Adam M BernsteinWalter C Willett
Feb 11, 2011·Diabetes/metabolism Research and Reviews·Luca BusettoFabio De Stefano
Oct 31, 2012·The British Journal of Nutrition·Margriet S Westerterp-PlantengaKlaas R Westerterp
Jul 23, 2013·Journal of the American Medical Directors Association·Jürgen BauerYves Boirie
Jan 31, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Rogerio F RibeiroWilliam C Stanley
May 13, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Nicolaas E P DeutzPhilip C Calder
Dec 20, 2014·Clinical Physiology and Functional Imaging·Dahan da Cunha NascimentoJonato Prestes
Jan 19, 2016·Life Sciences·Guilherme F SperettaDébora S A Colombari
Mar 2, 2016·International Journal of Sports Medicine·C A BarbozaB Rodrigues
Jun 4, 2016·The British Journal of Nutrition·Sonja MötteliTamara Bucher
Feb 22, 2017·International Journal of Sports Medicine·Ivo Vieira de Sousa NetoJonato Prestes
Jul 8, 2017·Journal of Applied Physiology·Vinicius GuzzoniHeloísa Sobreiro Selistre-de-Araújo
Sep 25, 2017·Journal of Dietary Supplements·Jay Rabindra Kumar Samal, Indira R Samal
Mar 8, 2018·International Journal of Medical Sciences·S F S MeloE M Oliveira
Apr 21, 2018·Nature Reviews. Cardiology·Michinari Nakamura, Junichi Sadoshima
May 23, 2018·Life Sciences·Michel Kendy SouzaAlvaro Pacheco E Silva Filho
Jun 5, 2018·Heart Failure Reviews·Monika BartekovaNaranjan S Dhalla
Jun 16, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Ana BatistaLuís B Sardinha
Apr 11, 2019·The American Journal of Clinical Nutrition·Heli E K VirtanenJyrki K Virtanen
Apr 16, 2019·Frontiers in Physiology·Marianna BellafioreAntonio Palma
May 24, 2019·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Tom L BroderickMarek Jankowski
Nov 16, 2019·Nature Reviews. Endocrinology·Bettina MittendorferLuigi Fontana

❮ Previous
Next ❯

Citations

Jun 18, 2021·The Journal of Experimental Biology·Alinne P CastroJeeser A Almeida

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomechanics

Biomechanics examines the generation of internal forces within the body and investigates the effects and control of forces that act on or are produced on tissues. Here are the latest discoveries.