High quantities of multidrug-resistant Escherichia coli are present in the Machángara urban river in Quito, Ecuador

Journal of Water and Health
David Ortega-ParedesJeannete Zurita

Abstract

Urban river pollution by multidrug-resistant (MDR) bacteria constitutes an important public health concern. Epidemiologically important strains of MDR Escherichia coli transmissible at the human-animal-environment interfaces are especially worrying. Quantifying and characterizing MDR E. coli at a molecular level is thus imperative for understanding its epidemiology in natural environments and its role in the spread of resistance in precise geographical areas. Cefotaxime-resistant E. coli was characterized along the watercourse of the major urban river in Quito. Our results showed high quantities of cefotaxime-resistant E. coli (2.7 × 103-5.4 × 105 CFU/100 mL). The antimicrobial resistance index (ARI) revealed the exposure of the river to antibiotic contamination, and the multiple antibiotic resistance index indicated a high risk of contamination. The blaCTX-M-15 gene was the most prevalent in our samples. Isolates also had class 1 integrons carrying aminoglycoside-modifying enzymes and folate pathway inhibitors. The isolates belonged to phylogroups A, B1 and D. Clonal complex 10 was found to be the most prevalent (ST10, ST44 and ST 167), followed by ST162, ST394 and ST46. Our study provides a warning about the high potential of...Continue Reading

References

Jan 1, 1995·Antimicrobial Agents and Chemotherapy·C LévesqueP H Roy
Jan 15, 2005·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Inger OlesenFrank Møller Aarestrup
May 13, 2006·Molecular Microbiology·Thierry WirthMark Achtman
May 18, 2006·Emerging Infectious Diseases·Armand PaauwMaurine A Leverstein-van Hall
Aug 31, 2006·Antimicrobial Agents and Chemotherapy·Xiaofei JiangYuan Lu
Oct 26, 2007·Journal of Clinical Microbiology·Alessandra CarattoliAlessandra Giordano
Feb 27, 2008·Journal of Applied Microbiology·M D BlascoE Alcaide
Jul 12, 2012·The Journal of Antimicrobial Chemotherapy·Ea ZankariMette Voldby Larsen
Apr 8, 2014·Environmental Monitoring and Assessment·Tandra Mohanta, Sudha Goel
Sep 3, 2016·Epidemiology and Infection·D Ortega-ParedesJ Zurita
Dec 1, 2013·Journal of Global Antimicrobial Resistance·Jeannete ZuritaMarcelo Mora
May 2, 2017·Clinics in Laboratory Medicine·Alina Iovleva, Yohei Doi
Jul 3, 2017·International Journal of Food Microbiology·Susana AraújoIsabel Henriques
Jul 18, 2017·Anaesthesiology Intensive Therapy·Katarzyna Talaga-ĆwiertniaMałgorzata Bulanda
Sep 13, 2017·Current Infectious Disease Reports·Pavithra Srinivas, Kaitlyn Rivard
Apr 8, 2018·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Yong ChongNobuyuki Shimono
Apr 8, 2018·Environment International·Célia M ManaiaOlga C Nunes
Apr 17, 2018·Pathogens·Carlos Chiluisa-GuachoMarise Dutra-Asensi
Aug 11, 2018·International Journal of Food Microbiology·Wataru HayashiNoriyuki Nagano
Sep 24, 2018·Plasmid·Monika Dolejska, Costas C Papagiannitsis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.