High rate of Helicobacter pylori reinfection in Lithuanian peptic ulcer patients

World Journal of Gastrointestinal Pathophysiology
Laimas JonaitisLimas Kupcinskas

Abstract

To evaluate the frequency of Helicobacter pylori (H. pylori) reinfection in peptic ulcer patients during 9 years after H. pylori eradication. We invited 117 peptic ulcer patients in whom eradication of H. pylori was confirmed 1 year after eradication treatment both by histology and by rapid urease test. In total, 57 patients were available for the study procedures: 34 (59.6%) male, 23 (40.4%) female; mean age 52.3 ± 13.0 years. There were 45 (78.9%) patients with duodenal ulcer and 12 (21.1%) with gastric ulcer. H. pylori was diagnosed by a rapid urease test and histology if endoscopy was performed. If endoscopy was refused, H. pylori was diagnosed by the C14-urea breath test and serology. H. pylori was established if at least one of the tests was positive. The mean follow-up was 8.9 ± 1.0 years (range, 6-12). H. pylori was established in 15 patients. In 2 H. pylori-negative patients, H. pylori was established during the follow-up period and eradicated. Therefore, we consider that reinfection occurred in 17 patients. In the per protocol analysis, reinfection was established in 17 of 57 (29.8%; 95%CI: 19.2-42.2) patients during the follow-up period. The annual rate of infection was 3.36%. If all non-responders were considered H....Continue Reading

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Citations

Nov 25, 2017·Experimental & Molecular Medicine·J K C Yee
Aug 9, 2017·World Journal of Gastroenterology : WJG·Vasiliy Ivanovich Reshetnyak, Tatiana Magomedalievna Reshetnyak
May 23, 2017·Frontiers in Cellular and Infection Microbiology·Yi HuNong-Hua Lu

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