High rate of HIV-1 drug resistance in treatment failure patients in Taiwan, 2009-2014

Infection and Drug Resistance
Hung-Chin TsaiYao-Shen Chen

Abstract

Drug resistance to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs) has been associated with loss of viral suppression measured by a rise in HIV-1 RNA levels, a decline in CD4 cell counts, persistence on a failing treatment regimen, and lack of adherence to combination antiretroviral therapy. This study aimed to monitor the prevalence and risk factors associated with drug resistance in Taiwan after failure of first-line therapy. Data from the Veterans General Hospital Surveillance and Monitor Network for the period 2009-2014 were analyzed. Plasma samples from patients diagnosed with virologic failure and an HIV-1 RNA viral load >1000 copies/mL were analyzed by the ViroSeq(™) HIV-1 genotyping system for drug susceptibility. Hazard ratios (HRs) for drug resistance were calculated using a Cox proportional hazard model. From 2009 to 2014, 359 patients were tested for resistance. The median CD4 count and viral load (log) were 214 cells/μL (interquartile range [IQR]: 71-367) and 4.5 (IQR: 3.9-5.0), respectively. Subtype B HIV-1 strains were found in 90% of individuals. The resistance rate to any of the three classes of antiretroviral drugs (NR...Continue Reading

Citations

Jul 12, 2018·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Viviane Machado Andrade, Mario Stevenson
Sep 21, 2019·Current Pharmaceutical Design·Umesh PanwarSanjeev K Singh
Apr 18, 2020·The Journal of Antimicrobial Chemotherapy·Yun LanFengyu Hu
Dec 9, 2020·AIDS Research and Human Retroviruses·Rachel SnoMalti R Adhin

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BETA
Genotyping

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SPSS

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