High rate of spontaneous negativity for hepatitis C virus RNA after establishment of chronic infection in Alaska Natives

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
John D ScottDavid Gretch

Abstract

Hepatitis C virus (HCV) leads to chronic infection in 70%-85% of exposed patients. Spontaneous clearance of the virus after chronic infection is believed to occur rarely. Alaska Natives who tested positive for HCV antibodies were enrolled in a prospective study that began in 1994 and were followed up on a regular basis. Individuals who tested positive for HCV RNA on 3 separate dates, each of which were at least 1 year apart, were included. Being negative for the virus was defined as having at least 1 negative HCV RNA test result after chronic viremia had been established. Of the 815 patients enrolled in the cohort, 139 met entry criteria and were observed for a mean period of 7.0 years. Eleven (8%) of the persons had at least 1 test in which HCV RNA was undetectable; 7 were classified as having either possible or probable clearance of the virus, corresponding to an annualized clearance rate of 0.74% per person-year (95% CI, 0.30%-1.53%). Of 9 patients who underwent subsequent HCV RNA testing, 5 (56%) had negative test results. A low HCV RNA level was significantly associated with spontaneous nondetectability of HCV RNA. Spontaneous HCV RNA negativity during chronic HCV infection is a surprisingly frequent event and is associate...Continue Reading

References

Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K IshiiT Miyamura
Nov 6, 2001·The American Journal of Gastroenterology·C O ZeinN N Zein
Nov 21, 2001·The Journal of Experimental Medicine·R ThimmeF V Chisari
Sep 27, 2002·The New England Journal of Medicine·Michael W FriedJian Yu
Oct 30, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M AugenbraunN Terrault
Feb 10, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brian J McMahonDavid R Gretch
May 14, 2004·Journal of Virology·Tram N Q PhamTomasz I Michalak
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Johannes WiegandHeiner Wedemeyer
Aug 17, 2004·The American Journal of Gastroenterology·Dana L BrudenLisa R Bulkow

❮ Previous
Next ❯

Citations

Jul 15, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Xu WangWen-Zhe Ho
Apr 8, 2010·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Tryambak SamantaSutapa Ganguly
Mar 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Georg M Lauer, Arthur Y Kim
Sep 25, 2009·Virology Journal·Mustafa Abdalla Ali AbouAbdelwahid Saeed Ali
Nov 7, 2009·Pharmacogenomics·Andri RauchPierre-Yves Bochud
Aug 14, 2008·World Journal of Gastroenterology : WJG·John D Scott, Naomi Garland
Oct 4, 2012·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Abdullah S AlghamdiUNKNOWN Saudi Association for the Study of Liver Diseases and Transplantation
Jun 25, 2009·Gastroenterology·Arthur Y Kim, Raymond T Chung
May 13, 2008·Gastroenterology·Sharif B MissihaE Jenny Heathcote
Mar 7, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A MangiaUNKNOWN Italian Association for the Study of the Liver (AISF)
Jan 8, 2008·Molecular Aspects of Medicine·Antonio CraxìAnna Linda Zignego
Jul 12, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tatsuya MinamiKazuhiko Koike
Apr 12, 2016·Research Synthesis Methods·S M GoringR W Platt
May 8, 2016·Journal of Hepatology·Naomi BulteelStephen T Barclay
Jul 28, 2017·International Journal of Molecular Sciences·Babita AgrawalRakesh Kumar
Nov 21, 2007·Journal of Viral Hepatitis·E Jenny Heathcote
Mar 19, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Francesca Mori UbaldiniMarina Nunez
Apr 4, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Barbara BertischUNKNOWN Swiss Hepatitis C Cohort Study
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Koko Bate AborsangayaJulia D Rempel
Oct 1, 2012·Hepatology International·Shiv K Sarin, Manoj Kumar
Jul 7, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hadi KuriryJordan J Feld

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.