High rate of transmission of tuberculosis in an office: impact of delayed diagnosis

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
C R MacIntyreG J Rouch

Abstract

We identified two cases of tuberculosis (TB) in office co-workers in Melbourne, Victoria, Australia; the Mycobacterium tuberculosis isolates were found to be identical with use of restriction fragment length polymorphism. Contact tracing was performed for 195 of 210 workers by means of the tuberculin skin test. Risk of infection was assessed according to a number of variables. Office contacts were exposed to infectious TB for 4 months; at least 24% of employees were infected. There was an association between sitting in proximity to the case during the period of exposure (OR, 4.24; 95% CI, 1.06-19.67). On-site workers had a higher risk of being infected (OR, 5.48; CI, 1.51-23.54) than did visiting workers. Workers in this office were exposed to open pulmonary TB for prolonged periods. The prevalence of TB infection (24%) among these workers was high compared with the infection rate (2%-7%) in the general community. Delay in diagnosis was the major factor responsible for the spread of TB in this office.

Citations

Feb 13, 2007·Epidemiology and Infection·C R MacIntyre
Mar 11, 2009·Epidemiology and Infection·J CastillaA Barricarte
Aug 20, 2010·Clinical and Vaccine Immunology : CVI·Gregory C IretonSteven G Reed
May 31, 2002·Journal of Clinical Microbiology·Celine GounderSusan E Dorman
Nov 5, 2013·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chen-Yu LiJung-Chung Lin
Sep 5, 2009·Diagnostic Microbiology and Infectious Disease·Walid Ben-SelmaJalel Boukadida
Dec 15, 2016·Case Reports in Emergency Medicine·Ines GriesshammerMoritz Steib

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