High ratio of T790M to EGFR activating mutations correlate with the osimertinib response in non-small-cell lung cancer

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Ryo AriyasuRyohei Katayama

Abstract

Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that can overcome resistance due to the Thr790Met (T790M) mutation. However, osimertinib occasionally shows limited efficacy in a small population of patients. We investigated the correlation between the ratio of T790M to EGFR activating mutation and the response to osimertinib. Between April 2016 and April 2017, 44 patients started osimertinib therapy at the Cancer Institute Hospital of the Japanese Foundation for Cancer Research. We performed EGFR mutation analysis of cytological samples from 33 patients using droplet digital PCR. We calculated the ratio of T790M to EGFR activating mutations and correlated it with the systemic response to osimertinib. In tumors from the 33 patients, the average ratio of T790M to EGFR activating mutations was 0.420. Twenty-one of the 33 patients had tumors with a T790M ratio of ≥0.4. The osimertinib response rate was significantly higher (92.3%) in patients with a T790M ratio of ≥0.4 than in those with a T790M ratio of <0.4 (52.6%; p = 0.0237). We examined the correlation between the T790M ratio and the tumor reduction rate and obtained a coefficient of r = 0.417 (p = 0.0175). In patients with a...Continue Reading

Citations

Nov 22, 2018·Expert Review of Anticancer Therapy·Riziero Esposito AbateNicola Normanno
Nov 27, 2018·International Journal of Cancer. Journal International Du Cancer·Shuyuan WangBaohui Han
Aug 9, 2019·Journal of Cellular and Molecular Medicine·Puyuan XingYuankai Shi
Jan 3, 2020·Journal of Cellular and Molecular Medicine·Xiaozhen LiuCaicun Zhou
Jan 7, 2020·Archives of Pathology & Laboratory Medicine·Shara Kamil NizamaddinSinchita Roy-Chowdhuri

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