High remnant lipoprotein levels in patients with variant angina

Clinical Cardiology
Kunihisa MiwaAtaru Taniguchi

Abstract

Dyslipidemia with increased oxidative stress but without elevation of low-density lipoprotein cholesterol has been recently implicated in the pathogenesis of coronary vasospasm. Disordered triglyceride-rich lipoprotein metabolism may be linked to the genesis of coronary artery spasm. Both serum remnant lipoprotein (RLP) and alpha-tocopherol levels were determined in 18 patients with the active stage of variant angina (VA), in 16 patients with the inactive stage of variant angina (IVA), and in 19 control subjects (CONTROL). The RLP levels were significantly (p < 0.05) higher in VA (6.4 +/- 2.7 mg/dl) than in IVA (4.4 +/- 1.5 mg/dl). In contrast, alpha-tocopherol levels were significantly lower in VA than that in CONTROL. Serum trigyceride levels were not significantly different among the study groups, although serum high-density lipoprotein cholesterol levels were significantly lower in VA than in CONTROL. Smoking was significantly (p < 0.05) more prevalent in VA (72%) than in IVA (25%) and CONTROL (37%). Serum RLP levels correlated positively with triglyceride levels (R = 0.73) and correlated inversely with alpha-tocopherol levels (R = -0.31) significantly in all study subjects. Patients with active stage of variant angina had ...Continue Reading

References

Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J R PatschS Eisenberg
Nov 11, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J R PatschW Patsch
Nov 28, 1986·JAMA : the Journal of the American Medical Association·W P CastelliW B Kannel
Mar 15, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·M G Mead, W G Dangerfield
Apr 1, 1995·The Journal of Clinical Investigation·J K Liao, S L Clark
Sep 1, 1993·The Journal of Clinical Investigation·S FazioS C Rall
Jan 1, 1993·Circulation·M Sugiishi, F Takatsu
Jul 1, 1996·Circulation·K MiwaH Inoue
Jul 11, 1998·Cardiovascular Research·K MiwaH Inoue

❮ Previous
Next ❯

Citations

Feb 25, 2005·Current Atherosclerosis Reports·ThB TwicklerJ S Cohn
Feb 2, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Katsuyuki NakajimaAkira Tanaka
Dec 26, 2012·Journal of the American College of Cardiology·Anette VarboBørge G Nordestgaard
Jun 5, 2008·Journal of cardiology·Hirofumi YasueYuji Mizuno

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.