High-resolution computed tomography and health-related quality of life in Mycobacterium avium complex disease

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
K MaekawaM Mishima


Kyoto, Japan. To validate the St George's Respiratory Questionnaire (SGRQ) in pulmonary Mycobacterium avium-intracellulare complex disease and to analyse the significance of high-resolution computed tomography (HRCT) findings as determinants of health-related quality of life (HRQoL) after adjusting for clinical and physiological parameters. Eighty-five patients completed the SGRQ, pulmonary function tests and other patient-reported measurements. HRCT findings were assessed using an established computed tomography (CT) scoring method. The SGRQ was validated with good internal consistency, test-retest reliability and significant correlations with most physiological variables and other patient-reported measurements. White blood cell counts, C-reactive protein levels, sputum culture results, treatment history, total CT scores, and consolidation, cavity and lobar volume-decrease CT component scores were significantly correlated with the SGRQ total and component scores. Stepwise multiple regression analyses revealed that the consolidation, cavity and lobar volume-decrease component scores were correlated with the SGRQ total and/or component scores. The total CT scores had the strongest relationships with the SGRQ total scores among t...Continue Reading


Jun 13, 2001·Biochemical and Biophysical Research Communications·Kiyotaka Fujita, K Takegawa
Nov 6, 2015·Annals of the American Thoracic Society·Christopher A CzajaGary R Cott
Feb 15, 2014·Asia Pacific Allergy·Woo-Jung SongAlyn H Morice

Related Concepts

C-reactive protein
Differential White Blood Cell Count Procedure
Quality of Life
Regression Analysis
Respiratory Function Tests
Sputum, Induced
Tomography, X-Ray Computerized Axial
Mycobacterium Avium-intracellulare Infection

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