High-resolution computed tomography in young patients with cystic fibrosis: distribution of abnormalities and correlation with pulmonary function tests

The Journal of Pediatrics
Alan S BrodyRobert W Wilmott

Abstract

To assess pulmonary abnormalities detected by high-resolution computed tomography (HRCT) in young children with cystic fibrosis (CF) and mild to moderate lung disease. High-resolution computed tomography was performed in 60 children, 6 to 10 years old, with mild to moderate lung disease (forced expiratory volume in 1 minute [FEV(1)], 52-137; mean, 102; SD, 15% predicted). HRCTs were scored by using a system that evaluates each lobe for severity and extent of CF lung disease. Findings of CF lung disease were tabulated in all subjects and in a subgroup with normal pulmonary function tests. HRCT scores were correlated with FEV(1), forced vital capacity (FVC), and forced expiratory flow between 25% and 75% of expired vital capacity (FEF(25-75)) in 57 patients. Bronchiectasis was present in 35% of subjects, mucous plugging in 15%, and air trapping in 63%. No abnormality was detected in 25%. In 37 subjects with FEV(1), FVC, and FEF(25-75) >85% predicted, bronchiectasis was present in 30%. In 17% of these subjects, bronchiectasis was seen in > or =4 lobes. Correlations between HRCT scores and FEV(1) were significant and showed fair to moderate correlation (r=0.36-0.46). High-resolution computed tomography demonstrated a broad range of...Continue Reading

References

Jun 1, 1991·Radiology·M BhallaD P Naidich
Jun 1, 1982·Journal of Computer Assisted Tomography·D P NaidichS S Siegelman
Apr 1, 1995·American Journal of Respiratory and Critical Care Medicine·T Z KhanD W Riches
Feb 1, 1993·Pediatric Pulmonology·X WangB G Ferris
Jan 1, 1996·Journal of Thoracic Imaging·M MaffessantiF Piovesana
Apr 29, 1998·Journal of Thoracic Imaging·D ChenK N Lee
Sep 21, 2000·European Radiology·F LaurentJ M Tunon-de-Lara
Apr 18, 2002·AJR. American Journal of Roentgenology·Hiroaki ArakawaW Richard Webb

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Citations

Apr 12, 2005·Pediatric Radiology·Frederick R LongRobert G Castile
Jul 4, 2012·European Radiology·Kristina Vult von SteyernMats Geijer
Dec 7, 2013·Annals of Biomedical Engineering·Maged AwadallaDavid A Stoltz
Apr 20, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Susan HoeReinhard Vehring
Apr 25, 2006·Archives of Disease in Childhood·S C Langton Hewer
Nov 24, 2006·Thorax·Sooky LumUNKNOWN London Cystic Fibrosis Collaboration
Jul 30, 2005·American Journal of Respiratory and Critical Care Medicine·Tanya M MartínezRobert S Tepper
Aug 16, 2005·American Journal of Respiratory and Critical Care Medicine·Alan S BrodyUNKNOWN CT Scanning in Cystic Fibrosis Special Interest Group
Oct 29, 2005·American Journal of Respiratory and Critical Care Medicine·Pim A de JongDon D Sin
Feb 17, 2007·American Journal of Respiratory and Critical Care Medicine·Stephanie D DavisMargaret W Leigh
Jul 14, 2010·American Journal of Respiratory and Critical Care Medicine·Isabelle Sermet-GaudelusLangdon L Miller
Jul 9, 2011·American Journal of Respiratory and Critical Care Medicine·Don B SandersPhilip M Farrell
Oct 4, 2011·American Journal of Respiratory and Critical Care Medicine·Cori Daines, Wayne Morgan
Mar 10, 2012·American Journal of Respiratory and Critical Care Medicine·Martine LoeveUNKNOWN Computed Tomography Cystic Fibrosis Survival Study Group
Oct 8, 2011·American Journal of Respiratory Cell and Molecular Biology·Dana WillnerForest Rohwer
Jul 27, 2007·Proceedings of the American Thoracic Society·Bonnie W Ramsey
Jul 27, 2007·Proceedings of the American Thoracic Society·Nicole Mayer-HamblettRichard A Kronmal
Jul 27, 2007·Proceedings of the American Thoracic Society·Stephanie D DavisMargaret Rosenfeld
Apr 24, 2007·AJR. American Journal of Roentgenology·Marcus P KennedyPaul L Molina
Aug 26, 2009·Radiology·Milene T Saavedra, David A Lynch
Oct 31, 2013·American Journal of Respiratory and Critical Care Medicine·Ryan J AdamDavid A Stoltz
Nov 23, 2013·Annals of the American Thoracic Society·Don B SandersPhilip M Farrell
Oct 18, 2013·Thorax·Lena P ThiaUNKNOWN London Cystic Fibrosis Collaboration
Jan 17, 2014·American Journal of Respiratory and Critical Care Medicine·Stephen A RowanJ Stuart Elborn
Dec 18, 2013·American Journal of Respiratory and Critical Care Medicine·James D ChalmersAdam T Hill
Aug 26, 2014·Journal of Pediatric Surgery·Vladimir GatzinskyPer Gustafsson
Apr 15, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Carla-Federica BortoluzziBaroukh M Assael
Aug 29, 2014·Pediatric Radiology·Alistair D CalderCatherine M Owens
Mar 19, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Pilar García-PeñaGoya Enríquez
Jul 9, 2004·The Journal of Pediatrics·Susanna A McColley

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