High resolution CT mammography of surgical biopsy specimens

Journal of Computer Assisted Tomography
V RaptopoulosC J D'Orsi

Abstract

Our goal was to assess the performance of high resolution CT on breast biopsy specimens before considering the reevaluation of refined CT techniques in patients with breast abnormalities. High resolution CT was done in 44 surgical biopsy specimens following conventional X-ray specimen mammography. The specimens comprised 38 palpable and nonpalpable soft tissue abnormalities with mean size of 19 mm and 6 specimens with clustered microcalcifications only. There were 21 carcinomas, 10 fibroadenomas, and 13 other benign conditions. Evaluation of CT and conventional images was done separately, and a feature-grading list was used to compare the two modalities. In fatty specimens, grading of morphologic features of masses and the confidence to detect a soft tissue abnormality were equal with both techniques. CT significantly improved the confidence to detect a mass in 17 specimens with dense tissue: On a scale of 0-10, the mean score for detection was 3.8 with radiography and 5.8 with CT (p<0.008). For clustered microcalcifications, X-ray was superior to CT. The mean CT attenuation of 18 malignant masses (82 HU) was significantly lower than the mean attenuation of 10 fibroadenomas (131 HU; p = 0.003). CT scans of the American College ...Continue Reading

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Citations

May 9, 2001·Breast Cancer : the Journal of the Japanese Breast Cancer Society·T UematsuK Shimizu
Oct 21, 2006·Journal of Mammary Gland Biology and Neoplasia·John M BooneThomas R Nelson
Mar 25, 2000·Surgical Oncology·V S KlimbergS Korourian
May 18, 2005·Medical Physics·Heang-Ping ChanBerkman Sahiner
May 18, 2007·Annual Review of Biomedical Engineering·Stephen J Glick
Dec 17, 2008·Medical Physics·Andrew Karellas, Srinivasan Vedantham
Aug 25, 2004·The Breast : Official Journal of the European Society of Mastology·M MuttalibH D Sinnett
May 21, 2013·Physics in Medicine and Biology·Srinivasan VedanthamStephen P Baker
Jan 11, 2018·Seminars in Ultrasound, CT, and MR·Avice M O'ConnellDaniel T Kawakyu-O'Connor

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