High-resolution CT of nontuberculous mycobacteria pulmonary infection in immunocompetent, non-HIV-positive patients

La Radiologia medica
R PolverosiB Feragalli


The objective of this study was to demonstrate that nontuberculous mycobacteria (NTM) pulmonary infections are not so infrequent and that the diagnosis may be suggested on the basis of the high-resolution computed tomography (HRCT) pattern alone. We retrospectively reviewed HRCT scans of 29 patients (9 men, 18 women; mean age 63 years, range 38-88 years) with positive culture from bronchial wash. Mycobacterium avium complex (MAC) was present in all (with the exception of one in whom the NTM was indistinct). In six patients, MAC was associated with M. chelonae, M. kansasii, M. fortuitum or M. xenopi. In one of these patients, MAC was associated with both M. fortuitum and M. chelonae. All patients had had nonspecific symptoms of pulmonary infection for a time ranging from 6 months to 12 years. Previous tuberculous infection was present in five patients (18.5%). Eleven patients had other pulmonary diseases (40.8%), and 12 had associated systemic diseases (44.4%). HRCT findings were apical fibrotic scarring (n=8; 29.6%), consolidations (n=16; 59.2%), single/multiple nodules >1 cm (n=8, multiple; 29.6%), cavitations (n=7; 25.9%), ground glass appearance (n=3; 11.1%), reticular/reticulonodular pattern (n=6; 22.2%), bronchiectasis (n=...Continue Reading


Sep 28, 1989·The New England Journal of Medicine·D S PrinceJ E Fish
Oct 14, 1998·American Journal of Respiratory and Critical Care Medicine·Richard J WallaceDavid E Griffith
Nov 11, 1999·Radiographics : a Review Publication of the Radiological Society of North America, Inc·J J ErasmusE F Patz
Mar 18, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S S Dhillon, C Watanakunakorn
May 10, 2002·The British Journal of Radiology·C Wittram, G L Weisbrod
Oct 18, 2005·Thorax·M WickremasingheR Wilson
Jun 30, 2006·The European Respiratory Journal·S J FowlerD Bilton
Jul 25, 2006·AJR. American Journal of Roentgenology·Jonathan D DoddNestor L Muller
Dec 2, 2006·The European Respiratory Journal·N Schönfeld
Dec 2, 2006·The European Respiratory Journal·M DaillouxFrench Mycobacteria Study Group
Feb 6, 2007·American Journal of Respiratory and Critical Care Medicine·David E GriffithInfectious Disease Society of America
Jun 21, 2007·AJR. American Journal of Roentgenology·Santiago MartinezChandra S Batchu
Jan 12, 2008·Chest·Jeffrey Glassroth


May 30, 2012·Clinics in Chest Medicine·David E Griffith, Timothy R Aksamit
Oct 31, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Diego J Maselli, Juan F Fernandez
Apr 5, 2011·Journal of Medical Microbiology·Fabio FabbianCarlo Contini
Sep 24, 2014·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jeong Jae KimSun Young Jeong
Dec 14, 2012·Expert Review of Respiratory Medicine·Curtis H Weiss, Jeffrey Glassroth

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.