High-resolution electrical mapping of depolarization and repolarization alternans in an ischemic dog model.

American Journal of Physiology. Heart and Circulatory Physiology
David GordonJason Ng

Abstract

Cardiac electrical alternans have been associated with spontaneous ventricular arrhythmias during myocardial ischemia. The study aims were to use a new algorithm to measure depolarization and repolarization alternans from epicardial electrograms in an ischemia model and to evaluate which features are predictive of ventricular fibrillation (VF). The left anterior descending coronary artery was occluded in 21 dogs, of which 6 developed spontaneous VF. Four seconds of unipolar epicardial electrograms was recorded before and 5 min after occlusion from an 8 x 14-electrode plaque placed on the anterior left ventricle. Alternans amplitudes were estimated with a triangular wave-fitting algorithm and for each unipolar electrogram for various measurements of the QRS and ST-T wave amplitude. The root mean square error was computed for each fit. Receiver-operator characteristic curves were used to determine whether prevalence of alternans having estimated alternans amplitude-to-error ratio (A/E) above a given threshold could distinguish the dogs who had and did not have spontaneous VF. The prevalence of alternans after ischemia was highly predictive of VF when measured both during depolarization (sensitivity of 83% and specificity of 87%) ...Continue Reading

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Citations

Oct 19, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Michael A KwofieJames B Martins
Nov 16, 2013·IEEE Transactions on Bio-medical Engineering·Michele OriniPier Lambiase
Jan 9, 2019·Journal of Cardiovascular Translational Research·Stefan M SattlerJacob Tfelt-Hansen
Jan 22, 2010·American Journal of Physiology. Heart and Circulatory Physiology·John E Madias
Jan 1, 2011·Current Opinion in Cardiology
Dec 3, 2021·Journal of the American Heart Association·Praloy ChakrabortyVijay S Chauhan

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