High-resolution entrainment mapping of gastric pacing: a new analytical tool.

American Journal of Physiology. Gastrointestinal and Liver Physiology
G O'GradyA J Pullan

Abstract

Gastric pacing has been investigated as a potential treatment for gastroparesis. New pacing protocols are required to improve symptom and motility outcomes; however, research progress has been constrained by a limited understanding of the effects of electrical stimulation on slow-wave activity. This study introduces high-resolution (HR) "entrainment mapping" for the analysis of gastric pacing and presents four demonstrations. Gastric pacing was initiated in a porcine model (typical amplitude 4 mA, pulse width 400 ms, period 17 s). Entrainment mapping was performed using flexible multielectrode arrays (</=192 electrodes; 92 cm(2)) and was analyzed using novel software methods. In the first demonstration, entrainment onset was quantified over successive waves in spatiotemporal detail. In the second demonstration, slow-wave velocity was accurately determined with HR field analysis, and paced propagation was found to be anisotropic (longitudinal 2.6 +/- 1.7 vs. circumferential 4.5 +/- 0.6 mm/s; P < 0.001). In the third demonstration, a dysrhythmic episode that occurred during pacing was mapped in HR, revealing an ectopic slow-wave focus and uncoupled propagations. In the fourth demonstration, differences were observed between paced...Continue Reading

References

Jul 1, 1973·The American Journal of Physiology·S K Sarna, E E Daniel
Mar 1, 1972·The American Journal of Physiology·K A Kelly, R C La Force
Jun 1, 1972·The American Journal of Physiology·S K SarnaY J Kingma
Feb 12, 1998·The American Journal of Physiology·Z Y LinJ D Chen
Mar 13, 1998·Gastroenterology·R W McCallumR A Ross
Jul 17, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·G HollopeterR D Palmiter
Aug 23, 2002·The American Journal of Gastroenterology·Mauro Bortolotti
Feb 14, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jinhong XingEdy Soffer
Dec 13, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J D Z ChenB Ross
Dec 17, 2005·The Journal of Physiology·G David S HirstFrank R Edwards
Aug 29, 2006·Medical & Biological Engineering & Computing·L Ver DonckB Coulie
Mar 8, 2008·Gastroenterology·Jieyun Yin, Jiande D Z Chen
Aug 21, 2008·Gastroenterology·Wim J E P LammersJan A J Schuurkes
Nov 8, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jan D Huizinga, Wim J E P Lammers
Mar 4, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·W L Hasler
Apr 11, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Wim J E P LammersJan A J Schuurkes
May 26, 2009·Surgical Endoscopy·Gregory O'GradyJohn A Windsor
Jun 10, 2009·World Journal of Surgery·Gregory O'GradyJohn A Windsor
Aug 1, 2009·IEEE Transactions on Bio-medical Engineering·Peng DuAndrew J Pullan
Dec 8, 2009·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Peng DuAndrew J Pullan
Feb 25, 2010·Chemical Society Reviews·Li-Jing Cheng, L Jay Guo

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Citations

Sep 8, 2012·Histochemistry and Cell Biology·Cornelia Irene HaglKarl-Herbert Schäfer
Jul 3, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gregory O'GradyAndrew J Pullan
Dec 8, 2010·Critical Reviews in Biomedical Engineering·Peng DuAndrew J Pullan
Oct 12, 2010·Annals of Biomedical Engineering·Jonathan C EricksonLeo K Cheng
Jan 2, 2015·Mathematical Medicine and Biology : a Journal of the IMA·Peng DuLeo K Cheng
May 27, 2014·IEEE Transactions on Bio-medical Engineering·Simon H BullLeo K Cheng
Dec 31, 2011·IEEE Transactions on Bio-medical Engineering·Niranchan PaskaranandavadivelLeo K Cheng
Jun 17, 2015·IEEE Transactions on Bio-medical Engineering·Shameer SatharLeo K Cheng
Apr 7, 2015·Journal of Neurogastroenterology and Motility·Amy A WorthKenton M Sanders
Jun 11, 2016·Neuromodulation : Journal of the International Neuromodulation Society·Timothy R AngeliGregory O'Grady
Apr 14, 2016·IEEE Transactions on Bio-medical Engineering·Niranchan PaskaranandavadivelLeo K Cheng
Aug 15, 2014·Clinical and Experimental Pharmacology & Physiology·Gregory O'GradyLeo K Cheng
Jul 12, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T H-H WangG O'Grady
Jul 14, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J U EgbujiA J Pullan
Jul 1, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G O'GradyA J Pullan
Dec 23, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G O'Grady
Jun 20, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G O'GradyL K Cheng
May 27, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·N PaskaranandavadivelG O'Grady
Dec 5, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ji-Hong ChenJan D Huizinga
Jan 31, 2018·Frontiers in Physiology·Peng DuLeo K Cheng
Apr 14, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Atchariya SukasemPeng Du
Dec 5, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Daniel A CarsonChristopher N Andrews
May 11, 2021·Frontiers in Neuroscience·Leo K ChengNiranchan Paskaranandavadivel
Oct 27, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Mohamed ElmasryThomas Abell

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