PMID: 11316531Apr 24, 2001Paper

High-resolution functional imaging with ultrasound contrast agents based on RF processing in an in vivo kidney experiment

Ultrasound in Medicine & Biology
X A VerbeekA P Hoeks

Abstract

Knowledge of the relative tissue perfusion distribution is valuable in the diagnosis of numerous diseases. Techniques for the assessment of the relative perfusion distribution, based on ultrasound (US) contrast agents, have several advantages compared to established nuclear techniques. These are, among others, a better spatial and temporal resolution, the lack of exposure of the patient to ionizing radiation and the relatively low cost. In the present study, US radiofrequency (RF) image sequences are acquired, containing the signal intensity changes associated with the transit of a bolus contrast agent through the microvasculature of a dog kidney. The primary objective is to explore the feasibility of calculating functional images with high spatial resolution. The functional images characterize the transit of the contrast agent bolus and represent distributions of peak time, peak value, transit time, peak area, wash-in rate and wash-out decay constant. For the evaluation of the method, dog experiments were performed under optimized conditions where motion artefacts were minimized and an IA injection of the contrast agent Levovist was employed. It was demonstrated that processing of RF signals obtained with a 3.5-MHz echo system...Continue Reading

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Citations

Feb 17, 2005·Investigative Radiology·Amy R BroumasKatherine W Ferrara
Apr 23, 2011·World Journal of Radiology·Marianne GauthierNathalie Lassau
Aug 31, 2010·Ultrasound in Medicine & Biology·Tamara RothsteinHaim Azhari
Oct 3, 2003·Radiologic Clinics of North America·Michelle L RobbinRichard G Barr
Sep 21, 2013·American Journal of Physiology. Renal Physiology·Anne-Emilie DeclèvesKumar Sharma
Mar 24, 2012·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Marianne GauthierNathalie Lassau

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