High-resolution genetic mapping of mammalian motor activity levels in mice

Genes, Brain, and Behavior
M J H KasP N E de Graan

Abstract

The generation of motor activity levels is under tight neural control to execute essential behaviors, such as movement toward food or for social interaction. To identify novel neurobiological mechanisms underlying motor activity levels, we studied a panel of chromosome substitution (CS) strains derived from mice with high (C57BL/6J strain) or low motor activity levels (A/J strain) using automated home cage behavioral registration. In this study, we genetically mapped the expression of baseline motor activity levels (horizontal distance moved) to mouse chromosome 1. Further genetic mapping of this trait revealed an 8.3-Mb quantitative trait locus (QTL) interval. This locus is distinct from the QTL interval for open-field anxiety-related motor behavior on this chromosome. By data mining, an existing phenotypic and genotypic data set of 2445 genetically heterogeneous mice (http://gscan.well.ox.ac.uk/), we confirmed linkage to the peak marker at 79 970 253 bp and refined the QTL to a 312-kb interval containing a single gene (A830043J08Rik). Sequence analysis showed a nucleotide deletion in the 3' untranslated region of the Riken gene. Genome-wide microarray gene expression profiling in brains of discordant F(2) individuals from CS ...Continue Reading

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Citations

May 18, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Amy F Eisener-DormanLisa M Tarantino
Oct 5, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Akinori NishiTsuyoshi Koide
Sep 11, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Joseph H NadeauToshihiko Shiroishi
Aug 15, 2009·Pharmacogenetics and Genomics·Heidi M B LesscherLouk J M J Vanderschuren
Jul 12, 2012·Epilepsia·Ellen V S HesselPierre N E de Graan
Apr 15, 2010·Physiological Genomics·Scott A KellyDaniel Pomp
Nov 12, 2009·Physiological Genomics·Scott A KellyDaniel Pomp
Mar 29, 2014·The European Journal of Neuroscience·Cigdem GelegenNicholas P Franks
Oct 20, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Annetrude J G de Mooij-van MalsenMartien J H Kas
Nov 10, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·C GelegenM J H Kas
Aug 21, 2009·Biological Psychiatry·Annetrude J G de Mooij-van MalsenMartien J Kas
Jun 20, 2013·Genes, Brain, and Behavior·J G de Mooij-van MalsenM J Kas
Oct 15, 2013·Genes, Brain, and Behavior·E Kostrzewa, M J Kas
Jun 11, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Martien J H KasDamiaan Denys
Jan 16, 2015·Annals of Clinical and Translational Neurology·Ellen V S HesselPierre N E de Graan
Oct 1, 2016·The European Journal of Neuroscience·Ellen V S HesselPierre N E de Graan

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