High resolution isotropic diffusion imaging in post-mortem neonates: a feasibility study

The British Journal of Radiology
Amy R McDowellOwen J Arthurs

Abstract

To investigate the potential of advanced diffusion weighted imaging (DWI) in post-mortem MRI (PMMR) at 3T. We acquired PMMR brain and body imaging in 12 neonates, mean gestational age 33.4 weeks (range 29-37 weeks) at 3T and 1.5T. Head and body diffusion imaging at 1.5T consisted of bipolar diffusion encoding and single-shot spin-echo echo-planar imaging (SE-EPI) for acquisition (echo time (TE) 96 ms; repetition time (TR) 2700 ms; voxel size 1.8 x 1.8 mm in-plane with slice thickness 5 mm; b-values of 500 and 1000 s/mm2 applied in three orthogonal directions; total acquisition time 2:12). A whole-body 3T diffusion imaging protocol using monopolar diffusion encoding and simultaneous multislice EPI acquisition with gradients applied in 12 uniformly distributed directions was obtained (TE 53.4 ms; TR 5600 ms; 1.8 mm isotropic; multiband factor 2; b-values of 250, 750, 1250 and 1750 s/mm2; acquisition time 2:09 for a single b-value). There was significant improvement in image quality in multiband, multislice diffusion PMMR protocol. On visual assessment of image quality, 1.5T DWI scored poorly (mean 2.4 SD ± 0.47), and all 3T b-values individually scored significantly higher (p < 0.001) apart from b = 250 s/mm2 which was not signif...Continue Reading

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Citations

Sep 17, 2019·Prenatal Diagnosis·Susan C ShelmerdineNeil J Sebire
Apr 25, 2020·The British Journal of Radiology·Amy R McDowellOwen J Arthurs

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