High resolution magnetic images of planar wave fronts reveal bidomain properties of cardiac tissue

Biophysical Journal
Jenny R HolzerFranz J Baudenbacher

Abstract

We magnetically imaged the magnetic action field and optically imaged the transmembrane potentials generated by planar wavefronts on the surface of the left ventricular wall of Langendorff-perfused isolated rabbit hearts. The magnetic action field images were used to produce a time series of two-dimensional action current maps. Overlaying epifluorescent images allowed us to identify a net current along the wavefront and perpendicular to gradients in the transmembrane potential. This is in contrast to a traditional uniform double-layer model where the net current flows along the gradient in the transmembrane potential. Our findings are supported by numerical simulations that treat cardiac tissue as a bidomain with unequal anisotropies in the intra- and extracellular spaces. Our measurements reveal the anisotropic bidomain nature of cardiac tissue during plane wave propagation. These bidomain effects play an important role in the generation of the whole-heart magnetocardiogram and cannot be ignored.

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Citations

Aug 9, 2008·Annals of Biomedical Engineering·Fei Yang, Robert Patterson
Nov 30, 2010·Biomedical Microdevices·Jesus A TapiaElías Manjarrez
Feb 22, 2005·Biophysical Journal·Rodrigo Weber dos Santos, Hans Koch
Nov 18, 2010·Biophysical Journal·Krista Kay McBrideFranz J Baudenbacher
Mar 28, 2008·Physics in Medicine and Biology·Yusuke SekiNaohide Ageyama
Jun 13, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Andrei IrimiaJohn P Wikswo
Nov 5, 2014·Physics in Medicine and Biology·Ville MäntynenMatti Stenroos

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