High-resolution magnetic resonance elastography reveals differences in subcortical gray matter viscoelasticity between young and healthy older adults

Neurobiology of Aging
Lucy V HiscoxJohn M Starr

Abstract

Volumetric structural magnetic resonance imaging (MRI) is commonly used to determine the extent of neuronal loss in aging, indicated by cerebral atrophy. The brain, however, exhibits other biophysical characteristics such as mechanical properties, which can be quantified with magnetic resonance elastography (MRE). MRE is an emerging noninvasive imaging technique for measuring viscoelastic tissue properties, proven to be sensitive metrics of neural tissue integrity, as described by shear stiffness, μ and damping ratio, ξ parameters. The study objective was to evaluate global and regional MRE parameter differences between young (19-30 years, n = 12) and healthy older adults (66-73 years, n = 12) and to assess whether MRE measures provide additive value over volumetric magnetic resonance imaging measurements. We investigated the viscoelasticity of the global cerebrum and 6 regions of interest (ROIs) including the amygdala, hippocampus, caudate, pallidum, putamen, and thalamus. In older adults, we found a decrease in μ in all ROIs, except for the hippocampus, indicating widespread brain softening; an effect that remained significant after controlling for ROI volume. In contrast, the relative viscous-to-elastic behavior of the brain...Continue Reading

Citations

Feb 27, 2019·Physics in Medicine and Biology·Matthew McGarryKeith Paulsen
Apr 9, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Prateek KalraArunark Kolipaka
Aug 3, 2019·Journal of Magnetic Resonance Imaging : JMRI·Tomohiro TakamuraHiroshi Onishi
May 2, 2020·The European Journal of Neuroscience·Chloe M HallGraham K Sheridan
Sep 16, 2020·Human Brain Mapping·Lucy V HiscoxCurtis L Johnson
Jan 31, 2020·Brain Communications·Lucy V HiscoxJohn M Starr
Oct 9, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·William C OliveroCurtis L Johnson
Oct 27, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Faria SanjanaChristopher R Martens
Dec 1, 2020·Frontiers in Cellular Neuroscience·Stefan J BlaschkeMaria A Rueger
Feb 20, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shreyan Majumdar, Dieter Klatt
Feb 23, 2021·NeuroImage·Lucy V HiscoxCurtis L Johnson
May 22, 2021·Frontiers in Bioengineering and Biotechnology·J Sebastian GiudiceMatthew B Panzer
May 26, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Marco Andrea ZampiniDieter Klatt
Oct 24, 2020·ACS Biomaterials Science & Engineering·Jacqueline M GodbeSamuel I Stupp

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Methods Mentioned

BETA
imaging technique

Software Mentioned

BrainSegNotVent
FMRIB Library
Linear Image Registration Tool
SPSS
MMRE
Advanced Normalization Tools ( ANTS )
FreeSurfer
FMRIB
power

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