High-resolution magnetic resonance imaging of the human median nerve

Neurorehabilitation and Neural Repair
Archie HeddingsWilliam Brooks

Abstract

It is widely accepted that peripheral nerve repairs performed within 6 weeks of injury have much better outcomes than those performed at later dates. However, there is no diagnostic technique that can determine if a traumatic peripheral nerve injury requires surgical intervention in the early postinjury phase. The objective of this article was to determine whether novel, noninvasive magnetic resonance imaging techniques could demonstrate the microstructure of human peripheral nerves that is necessary for determining prognosis and determining if surgery is indicated following traumatic injury. Ex vivo magnetic resonance imaging protocols were developed on a 9.4-T research scanner using spin-echo proton density and gradient-echo imaging sequences and a specially designed, inductively coupled radio frequency coil. These imaging protocols were applied to in situ imaging of the human median nerve in 4 fresh-frozen cadaver arms. Noninvasive high-resolution images of the human median nerve were obtained. Structures in the nerve that were observed included fascicles, interfascicular epineurium, perineurium, and intrafascicular septations. Application of these imaging techniques to clinical scanners could provide physicians with a tool ...Continue Reading

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Citations

Mar 17, 2006·European Radiology·Nicolae BologDominik Weishaupt
Jan 13, 2011·Journal of Neurology·Mirko PhamMartin Bendszus
Jan 13, 2006·Biomedical Engineering Online·Mehmet Bilgen
May 21, 2005·Journal of Magnetic Resonance Imaging : JMRI·Mehmet BilgenWilliam M Brooks
Feb 20, 2007·Muscle & Nerve·Michael S CartwrightWilliam W Campbell
Dec 31, 2014·Radiology Research and Practice·Paolo F FelisazStefano Bastianello

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