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High-resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans

Science

Feb 2, 2008

Graham CoopMolly Przeworski

Abstract

Recombination plays a crucial role in meiosis, ensuring the proper segregation of chromosomes. Recent linkage disequilibrium (LD) and sperm-typing studies suggest that recombination rates vary tremendously across the human genome, with most events occurring in narrow "hotspots." To exam...read more

Mentioned in this Paper

Transcription Initiation Site
Dysequilibrium Syndrome
Recombination, Genetic
Genetic Hotspot
Nucleotides
Meiosis
Chromosomes
Crossing Over, Genetic
Linkage Disequilibrium
M Phase, Meiotic
6
309
Paper Details
References
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  • Citations198
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  • References31
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High-resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans

Science

Feb 2, 2008

Graham CoopMolly Przeworski

PMID: 18239090

DOI: 10.1126/science.1151851

Abstract

Recombination plays a crucial role in meiosis, ensuring the proper segregation of chromosomes. Recent linkage disequilibrium (LD) and sperm-typing studies suggest that recombination rates vary tremendously across the human genome, with most events occurring in narrow "hotspots." To exam...read more

Mentioned in this Paper

Transcription Initiation Site
Dysequilibrium Syndrome
Recombination, Genetic
Genetic Hotspot
Nucleotides
Meiosis
Chromosomes
Crossing Over, Genetic
Linkage Disequilibrium
M Phase, Meiotic
6
309

Similar Papers Found In These Feeds

General Biology Journal eTOCs

Discover the latest general biology research in this collection of the top biology journals.

Stanford Department of Genetics

Find the latest research from the Stanford Medicine Department of Genetics here.

Related Papers

Paper Details
References
  • References31
  • Citations198
1234
  • References31
  • Citations198
12345...
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