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High-resolution mapping of expression-QTLs yields insight into human gene regulation

PLoS Genetics

Oct 11, 2008

Jean-Baptiste VeyrierasJonathan K Pritchard

Abstract

Recent studies of the HapMap lymphoblastoid cell lines have identified large numbers of quantitative trait loci for gene expression (eQTLs). Reanalyzing these data using a novel Bayesian hierarchical model, we were able to create a surprisingly high-resolution map of the typical locatio...read more

Mentioned in this Paper

Establishment and Maintenance of Localization
ATM wt Allele
Quantitative Trait Loci
Exons
Genome
Nucleic Acid Hybridization Procedure
Transcription Initiation Site
Recombination, Genetic
Transcription Initiation
Promoter
1
421
1
Paper Details
References
  • References46
  • Citations292
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  • References46
  • Citations292
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High-resolution mapping of expression-QTLs yields insight into human gene regulation

PLoS Genetics

Oct 11, 2008

Jean-Baptiste VeyrierasJonathan K Pritchard

PMID: 18846210

DOI: 10.1371/journal.pgen.1000214

Abstract

Recent studies of the HapMap lymphoblastoid cell lines have identified large numbers of quantitative trait loci for gene expression (eQTLs). Reanalyzing these data using a novel Bayesian hierarchical model, we were able to create a surprisingly high-resolution map of the typical locatio...read more

Mentioned in this Paper

Establishment and Maintenance of Localization
ATM wt Allele
Quantitative Trait Loci
Exons
Genome
Nucleic Acid Hybridization Procedure
Transcription Initiation Site
Recombination, Genetic
Transcription Initiation
Promoter
1
421
1

Similar Papers Found In These Feeds

RNA Splicing (Keystone)

The majority of human genes that encode proteins undergo alternative pre-mRNA splicing and mutations that affect splicing are more prevalent than previously thought. Discover the latest research on RNA splicing and co-transcriptional splicing in this feed.

Exon Skipping

Exon skipping is a method of RNA splicing used when a mutation occurs in the genes of exons. It is regulated largely by the use of antisense oligonucleotides that mask the mutated gene and allow the cellular machinery to skip over it. Exon skipping is being investigated as a therapeutic option for some diseases. Here is the latest research on exon skipping.

Related Papers

PLoS Biology

Mapping the genetic architecture of gene expression in human liver

PLoS BiologyMay 9, 2008
Eric E SchadtRoger Ulrich
Paper Details
References
  • References46
  • Citations292
12345
  • References46
  • Citations292
12345...
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