High-resolution mapping of meiotic crossovers and non-crossovers in yeast

Nature
Eugenio ManceraLars M Steinmetz

Abstract

Meiotic recombination has a central role in the evolution of sexually reproducing organisms. The two recombination outcomes, crossover and non-crossover, increase genetic diversity, but have the potential to homogenize alleles by gene conversion. Whereas crossover rates vary considerably across the genome, non-crossovers and gene conversions have only been identified in a handful of loci. To examine recombination genome wide and at high spatial resolution, we generated maps of crossovers, crossover-associated gene conversion and non-crossover gene conversion using dense genetic marker data collected from all four products of fifty-six yeast (Saccharomyces cerevisiae) meioses. Our maps reveal differences in the distributions of crossovers and non-crossovers, showing more regions where either crossovers or non-crossovers are favoured than expected by chance. Furthermore, we detect evidence for interference between crossovers and non-crossovers, a phenomenon previously only known to occur between crossovers. Up to 1% of the genome of each meiotic product is subject to gene conversion in a single meiosis, with detectable bias towards GC nucleotides. To our knowledge the maps represent the first high-resolution, genome-wide characte...Continue Reading

References

Nov 1, 1995·Genes & Development·B RockmillG S Roeder
Jan 1, 1995·Annual Review of Genetics·M Lichten, A S Goldman
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·F Baudat, A Nicolas
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·J L GertonT D Petes
Dec 2, 2000·Nature Genetics·M PrimigR E Esposito
May 2, 2001·Nature Reviews. Genetics·T D Petes
Sep 13, 2001·Current Biology : CB·I Gordo, B Charlesworth
Aug 9, 2003·Science·Scott L Page, R Scott Hawley
Jan 31, 2004·Genes & Development·Nancy M Hollingsworth, Steven J Brill
Jan 31, 2004·Nature Genetics·Jeffrey D Wall
Feb 18, 2004·Molecular Cell·Valérie BordeAlain Nicolas
Aug 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nancy KlecknerJohn Hutchinson
Oct 6, 2004·Genome Biology·Robert C GentlemanJianhua Zhang
Nov 24, 2004·Current Biology : CB·Christophe Kunz, Primo Schär
Dec 22, 2004·Genetics·Juan Lucas ArguesoEric Alani
Dec 29, 2004·Current Biology : CB·Kenneth J Hillers
Feb 17, 2005·BMC Bioinformatics·Guy St C Slater, Ewan Birney
Oct 4, 2005·Human Genomics·Matthew Hurles
Oct 26, 2005·Biochemical Society Transactions·M C Whitby
Mar 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lior DavidLars M Steinmetz
Jul 29, 2006·Cell·Emmanuelle MartiniScott Keeney
Mar 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Masahiro TerasawaTomoko Ogawa
Jul 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Wu WeiLars M Steinmetz
Aug 4, 2007·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Frédéric Baudat, Bernard de Massy
Sep 12, 2007·Nature Reviews. Genetics·Jian-Min ChenGeorge P Patrinos

❮ Previous
Next ❯

Citations

Mar 2, 2010·Journal of Molecular Evolution·Cheryl D Ambrose, Teresa J Crease
Oct 5, 2010·Journal of Molecular Evolution·Laurie S Stevison, Mohamed A F Noor
Aug 10, 2011·Chromosoma·Mónica Pradillo, Juan L Santos
Oct 29, 2013·Molecular Genetics and Genomics : MGG·Florence MougelMichel Solignac
Feb 28, 2013·European Journal of Human Genetics : EJHG·Badri Padhukasahasram, Bruce Rannala
Jun 16, 2011·Heredity·C S Smukowski, M A F Noor
Feb 13, 2009·Nature·Gianni LitiEdward J Louis
Oct 15, 2010·Nature·Cynthia R WagnerJudith L Yanowitz
Feb 1, 2013·Nature·Meleah A HickmanJudith Berman
Mar 6, 2012·Nature Cell Biology·Francesca ColeMaria Jasin
May 15, 2013·Nature Methods·Catherine L LudlowAimée M Dudley
Mar 13, 2013·Nature Reviews. Genetics·Asher D Cutter, Bret A Payseur
Feb 19, 2010·Nature Reviews. Molecular Cell Biology·Mariko SasakiScott Keeney
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·David GreshamDavid Botstein
Mar 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Phoebe S Lee, Thomas D Petes
Dec 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sihai YangDacheng Tian
Sep 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Doris Illner, Harry Scherthan
Feb 25, 2009·Bioinformatics·Richard BourgonWolfgang Huber
Jan 1, 2009·Genome Biology and Evolution·Claudia C Weber, Laurence D Hurst
Jun 15, 2011·Genome Biology and Evolution·John A Capra, Katherine S Pollard
Jul 29, 2011·Genome Biology and Evolution·Matthew K FujitaChris P Ponting
May 26, 2012·Genome Biology and Evolution·Eugénie PessiaGabriel A B Marais
Jan 29, 2013·Genome Biology and Evolution·Nicolas AgierGilles Fischer
Nov 2, 2013·Genome Biology and Evolution·Marie-Claude Marsolier-Kergoat
Jan 12, 2011·Journal of Experimental Botany·Bernd Edlinger, Peter Schlögelhofer
Jul 27, 2010·Molecular Biology and Evolution·Richard J Harrison, Brian Charlesworth
Jan 5, 2011·Molecular Biology and Evolution·Asher D Cutter, Alan M Moses
Mar 12, 2011·Molecular Biology and Evolution·Benoit NabholzHans Ellegren
Mar 30, 2011·Molecular Biology and Evolution·Juan S EscobarNicolas Galtier
Apr 21, 2011·Molecular Biology and Evolution·Aline MuyleSylvain Glémin
Nov 25, 2011·Molecular Biology and Evolution·Christopher J R IllingworthVille Mustonen
Dec 14, 2011·Molecular Biology and Evolution·Raquel Assis, Alexey S Kondrashov
Mar 1, 2013·Molecular Biology and Evolution·Nadezhda V TerekhanovaVladimir B Seplyarskiy
Nov 24, 2012·Nucleic Acids Research·Kai KruseM Madan Babu
Jul 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Abhirami RatnakumarMatthew T Webster
Apr 20, 2013·Genes & Development·Liisa KauppiScott Keeney
Sep 16, 2009·Genome Research·Wentian Li, Jan Freudenberg

❮ Previous
Next ❯

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