High-resolution mass spectrometers

Annual Review of Analytical Chemistry
Alan G Marshall, Christopher L Hendrickson

Abstract

Over the past decade, mass spectrometry has been revolutionized by access to instruments of increasingly high mass-resolving power. For small molecules up to approximately 400 Da (e.g., drugs, metabolites, and various natural organic mixtures ranging from foods to petroleum), it is possible to determine elemental compositions (C(c)H(h)N(n)O(o)S(s)P(p)...) of thousands of chemical components simultaneously from accurate mass measurements (the same can be done up to 1000 Da if additional information is included). At higher mass, it becomes possible to identify proteins (including posttranslational modifications) from proteolytic peptides, as well as lipids, glycoconjugates, and other biological components. At even higher mass ( approximately 100,000 Da or higher), it is possible to characterize posttranslational modifications of intact proteins and to map the binding surfaces of large biomolecule complexes. Here we review the principles and techniques of the highest-resolution analytical mass spectrometers (time-of-flight and Fourier transform ion cyclotron resonance and orbitrap mass analyzers) and describe some representative high-resolution applications.

References

Oct 13, 1998·Mass Spectrometry Reviews·A G MarshallG S Jackson
May 30, 2002·Analytical Chemistry·Alan G MarshallStone D H Shi
Nov 13, 2002·Omics : a Journal of Integrative Biology·Asaph AharoniDayan B Goodenowe
Nov 22, 2002·Journal of the American Society for Mass Spectrometry·Bruce E WilcoxAlan G Marshall
Apr 23, 2003·Analytical Chemistry·Mark Hardman, Alexander A Makarov
Dec 4, 2003·Journal of Mass Spectrometry : JMS·Michisato ToyodaItsuo Katakuse
Dec 13, 2003·Science·Simon RainvilleDavid E Pritchard
Jan 21, 2004·Accounts of Chemical Research·Alan G Marshall, Ryan P Rodgers
Jun 12, 2004·Analytical Chemistry·Neil L Kelleher
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·John E P SykaDonald F Hunt
Sep 25, 2004·Mass Spectrometry Reviews·Bogdan Bogdanov, Richard D Smith
Sep 25, 2004·Mass Spectrometry Reviews·Helen J CooperAlan G Marshall
Sep 25, 2004·Mass Spectrometry Reviews·Fanyu MengNeil L Kelleher
Jan 25, 2005·Molecular & Cellular Proteomics : MCP·Albrecht GruhlerOle N Jensen
Feb 8, 2005·Journal of the American Society for Mass Spectrometry·Lekha SlenoAlan G Marshall
Apr 20, 2005·Journal of Mass Spectrometry : JMS·Qizhi HuR Graham Cooks
Oct 27, 2005·Molecular & Cellular Proteomics : MCP·Jesper V OlsenMatthias Mann
Feb 16, 2006·Molecular & Cellular Proteomics : MCP·Boris MacekMatthias Mann
Feb 24, 2006·The Journal of Physical Chemistry. a·Qizhi HuRobert J Noll
Apr 4, 2006·Analytical Chemistry·Alexander MakarovStevan Horning
Jun 6, 2006·Journal of the American Society for Mass Spectrometry·Alexander MakarovStevan Horning
Dec 14, 2006·Molecular & Cellular Proteomics : MCP·Roman Zubarev, Matthias Mann
Mar 27, 2007·Journal of the American Society for Mass Spectrometry·Qizhi HuRobert J Noll
May 22, 2007·Journal of the American Society for Mass Spectrometry·Takaya SatohJun Tamura
Jun 8, 2007·Expert Review of Proteomics·David S Wishart
Jul 1, 1999·Analytical Chemistry·R J Cotter

❮ Previous
Next ❯

Citations

Sep 6, 2012·Journal of the American Society for Mass Spectrometry·Tawnya G Flick, Evan R Williams
May 30, 2013·Journal of the American Society for Mass Spectrometry·Jeremy A BarryDavid C Muddiman
Aug 29, 2013·Journal of the American Society for Mass Spectrometry·Wen Zhou, Kristina Håkansson
Oct 2, 2013·Journal of the American Society for Mass Spectrometry·Elise A DennisGary M Hieftje
Jun 27, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark R EmmettCarol L Nilsson
Sep 15, 2010·The Analyst·Jennifer M JohnsonDean P Jones
Feb 23, 2011·Molecular & Cellular Proteomics : MCP·Yi ShiJun Qin
Jul 20, 2010·Annual Review of Analytical Chemistry·Royce W Murray
Dec 22, 2011·Circulation. Cardiovascular Genetics·Han Zhang, Ying Ge
Jun 28, 2011·BMC Bioinformatics·Hiroki TakahashiShigehiko Kanaya
Mar 8, 2012·Bioanalysis·Yong LuoNing Fang
Nov 21, 2013·Journal of the American Society for Mass Spectrometry·Gelio AlvesYi-Kuo Yu
Apr 9, 2013·Annual Review of Analytical Chemistry·Corey N StedwellNicolas C Polfer
Mar 13, 2014·Pflügers Archiv : European journal of physiology·Zachery R GregorichYing Ge
May 3, 2014·Journal of the American Society for Mass Spectrometry·Tagir AushevYury O Tsybin
Apr 5, 2014·Journal of the American Society for Mass Spectrometry·Philip LösslAlbert J R Heck
May 1, 2012·Annual Review of Nutrition·Dean P JonesThomas R Ziegler
Jan 2, 2016·Toxicology Reports·Dean P Jones
Dec 17, 2015·Analytical Chemistry·Sung-Gun ParkJames E Bruce
Aug 7, 2012·International Journal of Mass Spectrometry·Yuan MaoAlan G Marshall
Jan 16, 2015·Mass Spectrometry Reviews·Tiago F JorgeCarla António
Sep 12, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Young-Mi GoDean P Jones
Mar 28, 2012·The Plant Journal : for Cell and Molecular Biology·Stephan KuegerPatrick Giavalisco
Dec 3, 2009·Proteomics·Joerg SeidlerWolf D Lehmann
Feb 14, 2015·Protein Science : a Publication of the Protein Society·Elisabetta Boeri Erba, Carlo Petosa
May 16, 2015·Mass Spectrometry Reviews·Tianyang GuoTianwei Tan
Jul 6, 2015·Analytical and Bioanalytical Chemistry·Clara IbáñezAlejandro Cifuentes
Mar 17, 2015·Journal of the American Society for Mass Spectrometry·Konstantin O NagornovYury O Tsybin
Nov 15, 2014·Journal of the American Society for Mass Spectrometry·Changgeng FengCarolyn J Cassady
Aug 27, 2016·Journal of the American Society for Mass Spectrometry·Elise A DennisGary M Hieftje

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear magnetic resonance
electron capture dissociation
glycosylation

Software Mentioned

SWIFT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Mass Spectrometry Reviews
Bogdan Bogdanov, Richard D Smith
Trends in Biotechnology
Rainer BreitlingMichael P Barrett
Analytical Chemistry
Feng XianAlan G Marshall
© 2021 Meta ULC. All rights reserved