High-resolution mass spectrometric determination of the synthetic cannabinoids MAM-2201, AM-2201, AM-2232, and their metabolites in postmortem plasma and urine by LC/Q-TOFMS

International Journal of Legal Medicine
Kei ZaitsuAkira Ishii

Abstract

High-resolution mass spectrometry and accurate mass measurement by liquid chromatography/quadrupole-time of flight mass spectrometry (LC/Q-TOFMS) was applied to postmortem plasma and urine specimens from an autopsy of a fatal case involving synthetic cannabinoid use, resulting in the detection of three synthetic cannabinoids: MAM-2201, AM-1220, and AM-2232. We searched for their metabolites existing in postmortem plasma or urine by LC/Q-TOFMS and were able to detect N-dealkylated metabolites, defluorinated and further oxidized metabolites of MAM-2201, and some hydroxylated metabolites. Postmortem plasma concentrations of the parent drugs, N-dealkylated metabolites, and fluorinated and further oxidized metabolites of MAM-2201 were measured, and quantitation results revealed site differences between heart and femoral postmortem plasma concentrations of parent drugs and some metabolites, suggesting postmortem redistribution of the synthetic cannabinoids and their metabolites. Quantitation results suggest that defluorination is a major metabolic pathway for MAM-2201, and N-dealkylation is a common but minor pathway for the naphthoylindole-type synthetic cannabinoids in human.

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Citations

Jul 3, 2016·Archives of Toxicology·H H Maurer, Markus R Meyer
Jun 24, 2017·Journal of Forensic Sciences·Kaori Shintani-IshidaHiroshi Ikegaya
Jul 4, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Piotr Adamowicz
Apr 25, 2020·Analytical and Bioanalytical Chemistry·Kentaro TakiKei Zaitsu
Jul 25, 2018·Archives of Pharmacal Research·Tae Yeon KongHye Suk Lee
Jun 29, 2018·Journal of the American Society for Mass Spectrometry·Karolina SekułaKarolina Lorek

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