High resolution mass spectrometry coupled with multivariate data analysis revealing plasma lipidomic alteration in ovarian cancer in Asian women

Talanta
Yangyang ZhangZhenwen Zhao

Abstract

Ovarian cancer (OC) is the most common cause of death from gynecologic malignancies in women. The identification of reliable diagnostic biomarkers for the early detection of this deadly disease is critical for reducing the mortality rate of OC. Plasma lysophosphatidic acid (LPA) levels were increased from OC patients vs. healthy controls. Therefore, lipidomics may represent an excellent developing prospect for the discovery of diagnostic biomarkers of OC. In this study, a nontargeted lipidomics approach based on ultra performance liquid chromatography-electrospray ionization-QTOF-mass spectrometry (UPLC-ESI-QTOF-MS) combined with multivariate data analysis, including principal component analysis (PCA) and (orthogonal) partial least squared discriminant analysis [(O)PLS-DA] was applied for the investigation of potential diagnostic biomarkers in plasma of OC patients. Patients with OC could be distinguished from healthy individuals and patients with benign gynecological tumor disease by this method, which shows a significant lipid perturbation in this disease. With the assistance of high resolution and high accuracy of MS and MS/MS data, the potential markers including lysophosphatidylcholines (LPCs), phosphatidylcholines (PCs) a...Continue Reading

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Citations

Oct 30, 2016·Trends in Biochemical Sciences·Kui Yang, Xianlin Han
Dec 6, 2016·International Journal of Molecular Sciences·Francesca PerrottiDamiana Pieragostino
May 5, 2017·Analytical Chemistry·Laura GoracciGabriele Cruciani
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Mar 30, 2018·Frontiers in Endocrinology·Yannick Audet-DelageChantal Guillemette
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Oct 28, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yousra Ahmed-SalimSrdjan Saso
May 8, 2020·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Xinlu WangJing Qiu
Oct 21, 2020·Cancer Letters·Zhangxiao PengChangqing Su
Jun 11, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Paulina BanachEwa Nowak-Markwitz

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