High-resolution myelin water imaging in post-mortem multiple sclerosis spinal cord: A case report

Multiple Sclerosis : Clinical and Laboratory Research
Cornelia LauleG R Wayne Moore

Abstract

Loss of myelin in the spinal cord in multiple sclerosis (MS) is likely an important, and early, contributor to atrophy and associated disability. In vivo measurement of myelin is possible using myelin water fraction (MWF) imaging, but MWF has never been assessed in MS along the entire length of the spinal cord in vivo or in post-mortem tissue. To assess the feasibility of measuring the distribution of MWF along the entire length of the spinal cord in post-mortem MS tissue using high-field MRI. One formalin-fixed spinal cord from a female with secondary progressive MS (age: 78 years, disease duration: 25 years) was cut into 104 5-mm-thick cross sections along the entire length of the spinal cord from the cervico-medullary junction to the conus medullaris and imaged using a 64 echo T2 relaxation experiment at 7T. Myelin water maps showed cord anatomy in superb detail, white matter demonstrating a higher MWF than the grey matter. Anatomical variation in myelin distribution along cervical, thoracic and lumbar regions was observed. Lesions demonstrated myelin loss. Post-mortem myelin water imaging of formalin-fixed MS spinal cord is feasible.

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Citations

Oct 5, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Daniel Ontaneda, Robert J Fox
Aug 5, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kedar R Mahajan, Daniel Ontaneda
Feb 18, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Sarah R MorrisCornelia Laule
Mar 7, 2020·Expert Review of Neurotherapeutics·Maria A RoccaMassimo Filippi
May 2, 2019·Therapeutic Advances in Neurological Disorders·Marcello MocciaOlga Ciccarelli
Jul 28, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Hanwen LiuCornelia Laule
Dec 21, 2016·Brain Plasticity·Alex L MacKay, Cornelia Laule
Nov 27, 2018·NeuroImage·Hyeong-Geol ShinJongho Lee
Nov 17, 2020·Frontiers in Human Neuroscience·Christian BeaulieuCornelia Laule
Jul 27, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Irene M VavasourCornelia Laule

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