High-resolution photoacoustic endoscope through beam self-cleaning in a graded index fiber

Optics Letters
Yi ZhangJi-Xin Cheng

Abstract

Intravascular photoacoustic imaging can potentially improve the identification of lipid-laden atherosclerotic plaque. Most intravascular photoacoustic endoscopes use multimode fibers, which do not allow tight focusing of photons. Recent experiments on pulse propagation in multimode graded-index fibers have shown a nonlinear improvement in beam quality. Here, we harness this nonlinear phenomenon for fiber-delivery of nanosecond laser pulses. We built a photoacoustic catheter 1.4 mm outer diameter, offering a lateral resolution as fine as 30 μm within a depth range of 2.5 mm. Such resolution is one order of magnitude better than current multimode fiber-based intravascular photoacoustic catheters. At the same time, the delivered pulse energy can reach as high as 20 μJ, which is two orders of magnitude higher than that of an optical resolution photoacoustic endoscope built with a single mode fiber. These improvements are expected to promote the biomedical application of photoacoustic endoscopes which require both high resolution and high pulse energy.

References

May 19, 2009·Optics Letters·Joon-Mo YangLihong V Wang
Mar 19, 2014·Ultrasound in Medicine & Biology·Krista JansenAntonius F W van der Steen
Jun 3, 2014·Journal of Biomedical Optics·Joon-Mo YangLihong V Wang
Mar 24, 2015·Biomedical Optics Express·Joon-Mo YangLihong V Wang
Apr 14, 2018·Optics Letters·Kedi XiongDa Xing

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Citations

May 1, 2020·Scientific Reports·K KrupaV Couderc
May 15, 2020·Optics Express·Y LeventouxV Couderc
Jul 28, 2020·Journal of Biomedical Optics·Eduardo A Gonzalez, Muyinatu A Lediju Bell
Nov 26, 2020·Scientific Reports·Marc FabertVincent Couderc
Jan 16, 2021·Lab on a Chip·Misagh Rezapour SarabiSavas Tasoglu
Nov 10, 2020·Photoacoustics·Jingcheng Zhou, Jesse V Jokerst

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