High-resolution Quantitative Computed Tomography Demonstrates Structural Defects in Cortical and Trabecular Bone in IBD Patients

Journal of Crohn's & Colitis
Judith HaschkaGeorg Schett

Abstract

To investigate the macro- and microstructural changes of bone in patients with inflammatory bowel disease [IBD] and to define the factors associated with bone loss in IBD. A total of 148 subjects, 59 with Crohn's disease [CD], 39 with ulcerative colitis [UC], and 50 healthy controls were assessed for the geometric, volumetric and microstructural properties of bone using high-resolution peripheral quantitative computed tomography. In addition, demographic and disease-specific characteristics of IBD patients were recorded. IBD patients and controls were comparable in age, sex, and body mass index. Total [p = 0.001], cortical [p < 0.001], and trabecular volumetric bone mineral density [BMD] [p = 0.03] were significantly reduced in IBD patients compared with healthy controls. Geometric and microstructural analysis revealed significantly lower cortical area [p = 0.001] and cortical thickness [p < 0.001] without differences in cortical porosity, pore volume, or pore diameter. CD showed a more severe bone phenotype than UC: cortical bone loss was observed in both diseases, but CD additionally showed profound trabecular bone loss with reduced trabecular BMD [p = 0.008], bone volume [p = 0.008], and trabecular thickness [p = 0.009]. Mul...Continue Reading

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Citations

Feb 23, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tobias SchmidtTim Rolvien
Jul 2, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gabriela Katharina MuschitzChristian Muschitz
Jun 2, 2017·The Journal of Clinical Investigation·Gabriel MbalavieleSteven L Teitelbaum
Sep 1, 2018·Arthritis Research & Therapy·Anna NeumannGeorg Schett
Jul 18, 2020·European Journal of Gastroenterology & Hepatology·Lewis SteellSze Choong Wong
Jan 26, 2021·Frontiers in Endocrinology·Zhengbo TaoLin Tao
Jan 10, 2021·Journal of Clinical Medicine·Judith HaschkaRoland Kocijan
Sep 4, 2021·Endocrine Reviews·Peter R EbelingFrances Milat

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