High-resolution repertoire analysis reveals a major bystander activation of Tfh and Tfr cells

Proceedings of the National Academy of Sciences of the United States of America
Paul-Gydeon G RitvoDavid Klatzmann

Abstract

T follicular helper (Tfh) and regulatory (Tfr) cells are terminally differentiated cells found in germinal centers (GCs), specialized secondary lymphoid organ structures dedicated to antibody production. As such, follicular T (Tfol) cells are supposed to be specific for immunizing antigens, which has been reported for Tfh cells but is debated for Tfr cells. Here, we used high-throughput T cell receptor (TCR) sequencing to analyze the repertoires of Tfh and Tfr cells, at homeostasis and after immunization with self- or foreign antigens. We observed that, whatever the conditions, Tfh and Tfr cell repertoires are less diverse than those of effector T cells and Treg cells of the same tissues; surprisingly, these repertoires still represent thousands of different sequences, even after immunization with a single antigen that induces a 10-fold increase in Tfol cell numbers. Thorough analysis of the sharing and network of TCR sequences revealed that a specific response to the immunizing antigen can only, but hardly, be detected in Tfh cells immunized with a foreign antigen and Tfr cells immunized with a self-antigen. These antigen-specific responses are obscured by a global stimulation of Tfh and Tfr cells that appears to be antigen-in...Continue Reading

References

Jan 1, 1994·Annual Review of Immunology·I C MacLennan
Dec 1, 1993·Seminars in Immunology·A K AbbasS A Bogen
May 1, 1996·Research in Immunology·R Medzhitov, C A Janeway
Jun 15, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Francisco J Quintana, Irun R Cohen
May 29, 2007·Nature Immunology·Nicolas FazilleauMichael G McHeyzer-Williams
Mar 3, 2009·Nature Immunology·Nicolas FazilleauMichael G McHeyzer-Williams
Aug 24, 2010·Immunological Reviews·Carola G VinuesaKatrina L Randall
Jul 26, 2011·Nature Medicine·Michelle A LintermanCarola G Vinuesa
Oct 11, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ivonne WollenbergLuis Graca
Jan 10, 2012·Annual Review of Immunology·Gabriel D Victora, Michel C Nussenzweig
Jan 29, 2016·Nature Communications·Meryem AloulouMichelle A Linterman
Apr 22, 2017·Nature Communications·Ana Raquel MaceirasLuis Graca
Jul 13, 2017·Proceedings of the National Academy of Sciences of the United States of America·James Badger WingShimon Sakaguchi

❮ Previous
Next ❯

Citations

Mar 16, 2019·Immunological Reviews·Válter R FonsecaLuis Graca
Jul 11, 2019·Nature Reviews. Rheumatology·Jun DengDi Yu
Jun 22, 2020·Immunological Reviews·James B WingShimon Sakaguchi
May 12, 2020·Clinical Reviews in Allergy & Immunology·Yuan YaoZhe-Xiong Lian
Dec 19, 2019·Frontiers in Immunology·Tingting DingCaihong Wang
Oct 17, 2019·Frontiers in Immunology·Mikhail V Pogorelyy, Mikhail Shugay
Feb 23, 2020·Clinical & Translational Immunology·Yao HuangShenghao Tu
Oct 20, 2019·Biomedical Journal·Meryem Aloulou, Nicolas Fazilleau
Jan 10, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Mostafa T MohammedPeter T Sage
Feb 20, 2021·Frontiers in Immunology·Caroline DudreuilhGiovanna Lombardi
Apr 27, 2021·Frontiers in Immunology·Xundong WeiXuyu Zhou
May 30, 2021·Science Immunology·Saumya KumarLuis Graca
Apr 15, 2021·Annual Review of Chemical and Biomolecular Engineering·Margarita PertsevaSai T Reddy
Aug 24, 2021·The Journal of Experimental Medicine·Balthasar A HeestersHergen Spits
Dec 24, 2021·The Biochemical Journal·Camila R R BarbosaMichele Mishto

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.