PMID: 7540934Apr 1, 1995Paper

High resolution structures of HIV-1 RT from four RT-inhibitor complexes

Nature Structural Biology
J RenD Stuart

Abstract

We have determined the structures of four complexes of HIV-1 reverse transcriptase with non-nucleoside inhibitors, three fully refined at high resolution. The highest resolution structure is of the RT-nevirapine complex which has an R-factor of 0.186 and a root-mean-square bond length deviation of 0.015 A for all data to 2.2 A. The structures reveal a common mode of binding for these chemically diverse compounds. The common features of binding are largely hydrophobic interactions and arise from induced shape complementarity achieved by conformational rearrangement of the enzyme and conformational/configurational rearrangement of the compounds.

References

Oct 15, 1979·Journal of Molecular Biology·D I StuartD K Stammers
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D RichmanJ Griffin
Mar 1, 1991·Acta Crystallographica. Section A, Foundations of Crystallography·T A JonesM Kjeldgaard
Dec 29, 1989·Biochemical and Biophysical Research Communications·M BabaT Miyasaka
Jan 20, 1994·Biochemical Pharmacology·E De Clercq
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·S J SmerdonT A Steitz
Jan 1, 1994·AIDS Research and Human Retroviruses·A M VandammeJ Anne
Sep 30, 1994·Journal of Molecular Biology·D K StammersE F Garman
Apr 1, 1995·Nature Structural Biology·R EsnoufD Stuart
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A Jacobo-MolinaP Clark
Sep 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·UNKNOWN Collaborative Computational Project, Number 4

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Citations

Sep 14, 2006·Journal of Molecular Modeling·Ravindra K RawalSetu B Katti
Dec 29, 2007·Journal of Computer-aided Molecular Design·Nitin S SapreNeelima Sapre
Jan 25, 2008·Journal of Computer-aided Molecular Design·Robert D Clark
Jul 27, 2012·Journal of Computer-aided Molecular Design·Flavio BallanteRino Ragno
Jan 1, 1996·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·E De Clercq
Oct 12, 2007·Biochemical and Biophysical Research Communications·Iris Oz GleenbergAmnon Hizi
May 18, 2005·Bioorganic & Medicinal Chemistry·Yasser M LokshaErik B Pedersen
Feb 10, 2004·Protein Expression and Purification·Esther W HouSamuel H Wilson
Feb 1, 2003·Journal of Molecular Biology·Gilda TachedjianStephen P Goff
Feb 1, 1996·Current Opinion in Structural Biology·P RiceD R Davies
Mar 7, 2001·Bioorganic & Medicinal Chemistry Letters·T K VenkatachalamF M Uckun
Jan 5, 1999·Bioorganic & Medicinal Chemistry Letters·A B DyatkinJ R Proudfoot
Jan 3, 2003·Protein Expression and Purification·Louise E BirdDavid K Stammers
Oct 6, 2000·Journal of Molecular Graphics & Modelling·P A KellerR Griffith
Sep 13, 2001·Journal of Molecular Graphics & Modelling·J PeiX He
Oct 24, 2007·Journal of Chemical Information and Modeling·Gabriela BarreiroWilliam L Jorgensen
Aug 12, 1998·Nature Structural Biology·J M Grimes, D I Stuart
Aug 10, 2000·Nature Biotechnology·P De BerardinisJ Guardiola
Jun 1, 1995·Nature Medicine·R S Goody
Mar 17, 2012·Nature Reviews. Microbiology·Alan Engelman, Peter Cherepanov
Mar 1, 1997·Nature Structural Biology·K BebenekT A Kunkel

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