High-resolution three-dimensional probes of biomaterials and their interfaces

Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
K GrandfieldH Engqvist

Abstract

Interfacial relationships between biomaterials and tissues strongly influence the success of implant materials and their long-term functionality. Owing to the inhomogeneity of biological tissues at an interface, in particular bone tissue, two-dimensional images often lack detail on the interfacial morphological complexity. Furthermore, the increasing use of nanotechnology in the design and production of biomaterials demands characterization techniques on a similar length scale. Electron tomography (ET) can meet these challenges by enabling high-resolution three-dimensional imaging of biomaterial interfaces. In this article, we review the fundamentals of ET and highlight its recent applications in probing the three-dimensional structure of bioceramics and their interfaces, with particular focus on the hydroxyapatite-bone interface, titanium dioxide-bone interface and a mesoporous titania coating for controlled drug release.

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Citations

Feb 22, 2012·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·A N Cormack, A Tilocca
Jul 6, 2014·Biointerphases·Kathryn Grandfield, Håkan Engqvist
Nov 8, 2015·Micron : the International Research and Review Journal for Microscopy·William QueridoMarcos Farina
Jan 11, 2016·Journal of Biomedical Materials Research. Part a·Svetlana GorodzhaRoman A Surmenev
Apr 5, 2013·Nanoscale·Kathryn GrandfieldAnders Palmquist
Nov 12, 2018·ACS Biomaterials Science & Engineering·Dakota M Binkley, Kathryn Grandfield
Jan 9, 2017·ACS Biomaterials Science & Engineering·Xiaoyue WangKathryn Grandfield
Sep 9, 2021·Journal of the Royal Society, Interface·Chiara MichelettiKathryn Grandfield

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