High resting triacylglycerol turnover of rainbow trout exceeds the energy requirements of endurance swimming

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Leonardo MagnoniJean-Michel Weber

Abstract

Fish may use lipoproteins instead of albumin-bound fatty acids to fuel endurance exercise, but lipoprotein kinetics have never been measured in ectotherms. In vivo bolus injections of labeled very-low-density lipoproteins ((3)H-VLDL labeled in vivo from donor fish) and continuous infusions of Intralipid (3H-labeled artificial emulsion) were used to investigate the effects of prolonged exercise (6 h at 1.5 body length/s) and heparin (600 U/kg) on the turnover rate of circulating triacylglycerol (TAG) in rainbow trout. We hypothesized that swimming would stimulate TAG turnover rate to fuel working muscles and that heparin would reduce flux by releasing lipoprotein lipase (LPL) from endothelial cells. Results from both tracer methods show that the baseline TAG turnover rate of trout ranges from 24 to 49 mumol TAG.kg(-1) x min(-1) and exceeds all values measured to date in endotherms. More important, this high resting turnover rate is not stimulated during swimming, because it can already cover several times the energy requirements of locomotion. The fact that heparin causes a 50% decrease in baseline TAG turnover rate suggests that fish LPL must be bound to the endothelium for normal tissue uptake of fatty acids supplied by lipopr...Continue Reading

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Citations

Oct 17, 2013·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·A J HulbertSarah K Abbott
Mar 17, 2011·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jordan S Marit, Lynn P Weber
Jan 5, 2011·Toxicology and Applied Pharmacology·John S PrindivilleJean-Michel Weber
Sep 20, 2015·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Jan A Mennigen
Jun 3, 2015·Fish Physiology and Biochemistry·Edson RodriguesHelena Passeri Lavrado
Mar 9, 2018·The Journal of Experimental Biology·Christopher G Guglielmo
Jan 23, 2016·The Journal of Experimental Biology·Jean-Michel WeberTeye Omlin
Aug 15, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Teye OmlinJean-Michel Weber
Jun 27, 2012·Exercise and Sport Sciences Reviews·Grant B McClelland
Mar 20, 2020·The British Journal of Nutrition·N M WadeB D Glencross
Dec 8, 2017·The Journal of Experimental Biology·Eric D Turenne, Jean-Michel Weber
Oct 23, 2019·Frontiers in Physiology·Florence Hunter-ManseauPierre U Blier
Feb 17, 2009·The Journal of Experimental Biology·Jean-Michel Weber
Jul 16, 2008·The Journal of Experimental Biology·Leonardo MagnoniJean-Michel Weber
Apr 13, 2012·The Journal of Experimental Biology·Jean-Michel Weber, Shannon P Reidy
Nov 3, 2010·The Journal of Experimental Biology·Teye Omlin, Jean-Michel Weber
Dec 24, 2010·The Journal of Experimental Biology·Jean-Michel Weber

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